Singlet oxygen generating device for selective destruction of pathogens
A device for generating singlet oxygen is provided. The device has a sensitizer that converts triplet oxygen to single oxygen upon exposure to light. The device is configured to keep the sensitizer from contacting external fluids.
1. An assembly for treating a periodontal pocket, the assembly comprising:
an elongated optical fiber with a first width and a first height at a distal end and a second width and a second height at a proximal end, wherein the first height is greater than the second height;
a superhydrophobic polymer coating a terminal portion of the elongated optical fiber at the proximal end, wherein the superhydrophobic polymer is optically transparent and has a roughened surface with a water contact angle of at least 140°;
a sensitizer disposed on at least a surface of the superhydrophobic polymer, wherein the sensitizer converts triplet oxygen to singlet oxygen upon exposure to light.
2. The assembly as recited in claim 1 , wherein the second width is greater than the first width.
3. The assembly as recited in claim 1 , wherein the superhydrophobic polymer has a thickness between 50 and 500 microns.
4. The assembly as recited in claim 1 , wherein the first width is greater than the second width, thereby forming a narrowed terminus at the proximal end.
5. The assembly as recited in claim 4 , wherein the superhydrophobic polymer has length with a constant width over the length.
6. The assembly as recited in claim 4 , wherein the superhydrophobic polymer has a length with a width that changes over the length.
7. The assembly as recited in claim 4 , wherein the first width of the optical fiber is 1 mm.
8. The assembly as recited in claim 1 , wherein the superhydrophobic polymer is selected from a group consisting of a polydimethylsiloxane (PDMS), a fluorinated ethylene propylene (FEP) and a polytetrafluorethylene (PTFE).
9. The assembly as recited in claim 1 , wherein the roughened surface has first indentations with a first diameter of 1-20 microns and second indentations with a second diameter of 40-300 microns.
10. The assembly as recited in claim 1 , wherein the water contact angle of the roughened surface is at least 150°.
11. The assembly as recited in claim 1 , further comprising a light source operatively connected to the elongated optical fiber for delivering light through the elongated optical fiber, through the superhydrophobic polymer and to the sensitizer.
12. The assembly as recited in claim 1 , wherein the sensitizer is present at a surface concentration of at least 60 nanomoles per square centimeter.
13. The assembly as recited in claim 1 , wherein the sensitizer is present at a surface concentration of at least 600 nanomoles per square centimeter.
14. An assembly for treating a periodontal pocket, the assembly comprising:
an elongated optical fiber with a first width and a first height at a distal end and a second width and a second height at a proximal end, wherein the first height is greater than the second height;
a superhydrophobic terminal portion of the elongated optical fiber at the proximal end, wherein the superhydrophobic terminal portion is optically transparent and has a roughened surface with a water contact angle of at least 140°;
a sensitizer disposed on at least a surface of the superhydrophobic terminal portion, wherein the sensitizer converts triplet oxygen to singlet oxygen upon exposure to light.
15. The assembly as recited in claim 14 , wherein the elongated optical fiber and the superhydrophobic terminal portion consist of a monolithic hydrophobic polymer.
16. A method of treating a periodontal pocket, the method comprising steps of:
inserting, into a periodontal pocket, the proximal end of the assembly of claim 1 ;
illuminating the elongated optical fiber with a light source such that light contacts the sensitizer;
permitting the sensitizer to change ambient oxygen to singlet oxygen within the periodontal pocket.