Preventing non-target embolization
Devices, methods and kits for preventing or reducing non-target microparticles deposition and embolization, in conjunction with delivering microparticles (e.g., embolization material) via a blood vessel to a target bodily part. Applicable for entrapping infiltrated microparticles within heart right atrium. Entrapping device includes: filter; and filter collapsing mechanism sized for positioning in catheter lumen of a filter delivering catheter, and having proximal end actuatable from outside of subject. Filter configured for positioning within heart right atrium, for self-expanding and covering right atrium inlet opening, and configured, when expanded, to collect embolic material delivered to target organ and infiltrated into outflow vessel thereof draining to right atrium. Filter collapsing mechanism configured for collapsing, and being manipulated to form a pocket in filter, to entrap collected embolic material therein, and drawing filter with collected embolic material in pocket, into catheter lumen of filter delivering catheter.
1. A kit for preventing non-target deposition of embolization particles, said kit comprising:
an entrapping device configured for positioning within a right atrium and for covering an inlet opening of the right atrium, comprising a filter comprising a mesh configured to allow blood flow therethrough while entrapping embolization particles flowing toward the right atrium, thereby preventing the embolization particles from entering the right atrium, and a collapsing mechanism configured to turn the filter into a closed pocket preventing outflow of entrapped embolization particles therefrom; and
an embolization microcatheter configured for delivering the embolic particles to a target organ tubular wall, said embolization microcatheter comprising a distal outlet and a plurality of side openings distributed around and along a section of a wall of said embolization microcatheter proximally to the distal outlet; wherein said distal outlet is shaped and sized to facilitate delivery of the embolization particles and wherein each of said plurality of side openings is shaped and sized to block passage therethrough of the embolization particles while allowing outflow of fluid.
2. The kit of claim 1 , wherein the collapsing mechanism comprises a drawstring threaded around the perimeter of the filter.
3. The kit of claim 1 , wherein the mesh has strands with a thickness of 200 micrometers or less.
4. The kit of claim 1 , wherein the mesh has strands with a thickness of 100 micrometers or less.
5. The kit of claim 1 , wherein the mesh has strands with a thickness of 50 micrometers or less.
6. The kit of claim 1 , wherein pores of the mesh have a pore diameter of 100 micrometer or less.
7. The kit of claim 1 , wherein pores of the mesh have a pore diameter of diameter of 50 micrometer or less.
8. The kit of claim 1 , further comprising a vial containing the embolization particles.
9. The kit of claim 1 , wherein the filter has a parachute-like shape.
10. The kit of claim 9 , wherein the embolization particles have a diameter in the range of 10-1500 micrometer.
11. The kit of claim 9 , wherein the embolization particles have a diameter in the range of 10-500 micrometer.
12. The kit of claim 1 , wherein the filter is made of a polymeric material.
13. The kit of claim 12 , wherein the polymeric material is selected from the group of polypropylene (PP), polyvinylchloride (PVC), polyamide (nylon), polyurethane, polyester, polyethylene tetraphalate, polyether-ether ketone (PEEK), polyether block amide (PEBA), polytetraflouroethylene (PTFE), or any mixture, blend or combination thereof.
14. The kit of claim 1 , wherein the filter is made of metal alloy.
15. The kit of claim 14 , wherein the metal alloy is selected from stainless steel, nickel-titanium, platinum or cobalt chrome.
16. The kit of claim 1 , wherein the plurality of side openings are in a form of axial slits.