IP Library › Granted Patent US 11,938,208
Granted Patent B2
US 11,938,208 · App. 17/435,103 · Granted Mar 26, 2024

Antimicrobial mixture

Inventors: Imke Meyer (Bodenwerder, DE); Ravikumar Pillai (Mahwah, NJ)
Assignee: Symrise AG
A61K8/347A61K8/24A61K8/35A61K8/92A61P31/00
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Quick Facts
Patent No.
US 11,938,208
App. No.
17/435,103
Granted
Mar 26, 2024
Kind
B2
Abstract

Suggested is an antimicrobial mixture comprising or consisting of (a) at least one monocyclic sesquiterpene alcohol, (b) at least one active selected from the group consisting of 4-hydroxyacetophenone, sorbitan caprylate, cocamidopropyl PG-dimonium chloride phosphate, tetrasodium glutamate diacetate, glyceryl caprylate and glyceryl caprate, and optionally (c) at least one additional antimicrobial agent different from components (a) and (b).

Claims (66)

1. An antimicrobial mixture consisting of

(a) about 0.1 wt.-% of at least one α-bisabolol isomer,

(b) about 0.25 wt.-% to about 0.35 wt.-% of 4-hydroxyacetophenone, and

(c) the balance of at least one additional antimicrobial agent different from components (a) and (b),

on condition the amounts add to 100 wt.-%,

and present in an anti-microbially effective amount against mold species of the genus E. coli after 14 days at a minimum.

2. The mixture of claim 1 , comprising an α-bisabolol isomer mixture.

3. The mixture of claim 1 , wherein said α-bisabolol is of natural or synthetic origin.

4. The mixture of claim 1 , wherein components (a) and (b) are present in a ratio by weight of from about 10: 90 to about 90:10.

5. The mixture of claim 1 , wherein the at least one additional antimicrobial agent is a 1,2-alkanediol having 5 to 12 carbon atoms and/or phenoxyethanol.

6. The mixture of claim 5 , wherein said 1,2-alkanediol is selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decandiol, 1,2-dodecandiol, and mixtures thereof.

7. The mixture of claim 1 , wherein the at least one additional antimicrobial agent is selected from the group consisting of:

1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone, 2-

aminoethanol (Octopirox)

1,2-decanediol (SymClariol)

10-undecylenic acid and its salts,

2,4-hexadienoic acid (sorbic acid) and its salts (e.g. potassium salt),

2-phenoxyethanol,

3-Acetyl-2-hydroxy-6-methyl-4H-pyran-4-one (Dehydroacetic acid),

4-hydroxy acetophenone

4-hydroxy benzaldehyde,

alkyl-(C8-C18)-dimethyl-benzyl-ammonium chloride (Benzalkonium

chloride),

anisic acid and its salts,

benzoic acid and para-hydroxybenzoic acid, their esters and salts,

benzyl alcohol,

benzyl benzoate,

bis(2-pyridylthio)zinc 1,1′-dioxide, N,N′-(decane-1,10-diyldipyridin-1-yl-4-

ylidene)-dioctan-1-amine dihydrochloride (octenidine dihydrochloride),

caprylhydroxamic acid,

capryloyl glycin,

cetyl pyridium chloride,

chitosan,

chlorhexidine acetate,

chlorhexidine gluconate,

chlorhexidine hydrochloride,

cinnamic acid and its salts,

cinnamic alcohol,

cinnamic aldehyde,

Climbazole (Crinipan),

ethylene diamine tetra acetate (EDTA)

ethyl lauroyl arginate HCL

eugenol,

farnesol,

glyceryl monolaurate,

glyceryl caprylate

glyceryl caprate

levulinic acid and its salts,

ortho-, meta-, and para-anisic aldehyde,

perillic acid and its salts,

poly-(hexamethylenediguanide) hydrochloride,

propionic acid and its salts

salicylic acid and its salts,

sorbitan caprylate,

thymol,

tropolone,

undecenoyl glycin

3-[(2-Ethylhexyl)oxy]-1,2-propanediol (Ethlyhexyl glycerin)

2-Phenoxyethanol

3-Phenylpropanol

1,2-Pentanediol

1,2-Hexanediol

1,2-Octanediol

1,3-Propanediol

Lactic acid and its salts

8. The mixture of claim 6 , wherein said 1,2-alkanediol is a mixture of 1,2-hexanediol and 1,2-octanediol.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 19, 2021
From: MEYER, IMKE; PILLAI, RAVIKUMAR
To: SYMRISE AG
Reel/Frame 057833/0428 →
Continuity (2)
Provisional Application 62817008 · Mar 12, 2019
Related Publication 20220362119A1 · Nov 17, 2022