Modified peptides for use in treating neurodegenerative disorders
The invention relates to neurodegenerative disorders, and in particular to novel peptides, peptidomimetics, compositions, therapies and methods for treating such conditions, for example Alzheimer's disease.
1. A method of treating or ameliorating Alzheimer's disease, the method comprising administering, to a subject in need of such treatment, a therapeutically effective amount of a compound of Formula (I):
wherein:
R 1 is —NR 9 R 10 or —OH, either:
R 4 is
and R 6 is
(ii) R 2 is
R 4 is
and R 6 is
R 3 , R 5 , and R 7 are —H; R 8 is
R 9 and R 10 arc —H;
R 11 is an aryl group;
and
each n is 0, 1, 2, 3, or 4.
2. The method according to claim 1 , wherein the compound has Formula (Ia):
3. The method according to claim 1 , wherein R 1 is —NH 2 .
4. The method according to claim 1 , wherein R 2 is
R 4 is
and R 6 is
5. The method according to claim 1 , wherein R 2 is
R 4 is
and R 6 is
6. The method according to claim 1 , wherein the compound is a compound of Formula (101) or (103)
7. The method according to claim 6 , wherein the compound is a compound of Formula (101a), or (103a):