Multi-mode electrical stimulation systems and methods of making and using

1. A system for programming electrical stimulation of a patient using an implantable electrical stimulation system comprising an implantable pulse generator and a lead having a plurality of electrodes, the system comprising:

a processor configured to:

receive a first response for each of a plurality of first stimulations performed using a plurality of different first subsets of one or more of the electrodes of the lead, wherein each of the first stimulations uses one of the first subsets and each of the first subsets is used for at least one of the first stimulations, wherein the first stimulations are each configured to preferentially stimulate a first type of neural element over a second type of neural element by selection of at least one of a first value of a stimulation amplitude, a first type of a stimulation polarity, a first value of a pulse width, a first value of a pulse rate, or a first value of a pulse duration for the first stimulation;

select a one of the first subsets of one or more of the electrodes based, at least in part, on the first responses;

receive a second response for each of a plurality of second stimulations performed using a plurality of different second subsets of one or more of the electrodes, wherein each of the second stimulations uses one of the second subsets and each of the second subsets is used for at least one of the second stimulations, wherein the second stimulations are configured to preferentially stimulate the second type of neural element over the first type of neural element by selection of at least one of a second value of the stimulation amplitude, a second type of the stimulation polarity, a second value of the pulse width, a second value of the pulse rate, or a second value of the pulse duration for the second stimulation;

select a one of the second subsets of one or more of the electrodes based, at least in part, on the second responses;

select a programming subset of one or more of the electrodes based on the first and second responses associated with the selected one of the first subsets and the selected one of the second subsets, respectively;

receive direction to program the implantable pulse generator with the programming subset of one or more of the electrodes; and

initiate a signal that provides the implantable pulse generator of the implantable electrical stimulation system with the programming subset of one or more of the electrodes for generating electrical stimulation for the patient through the electrodes of the lead.

2. The system of claim 1 , wherein receiving a first response comprises receiving a first quantitative or qualitative indication of at least one therapeutic effect and receiving a second response comprises receiving a second quantitative or qualitative indication of at least one therapeutic effect.

3. The system of claim 1 , wherein receiving the first response comprises receiving a first quantitative or qualitative indication of at least one therapeutic effect, at least one side-effect, or any combination thereof and receiving the second response comprises receiving a second quantitative or qualitative indication of at least one therapeutic effect, at least one side-effect, or any combination thereof.

4. The system of claim 3 , wherein selecting the programming subset of one or more of the electrodes comprises selecting the programming subset of one or more of the electrodes based on the first and second quantitative or qualitative indications.

5. The system of claim 1 , wherein the processor is further configured to:

receive a third response for each of a plurality of third stimulations performed using a plurality of different third subsets of one or more of the electrodes, wherein each of the third stimulations uses one of the third subsets and each of the third subsets is used for at least one of the third stimulations, wherein the third stimulations are configured to preferentially stimulate a third type of neural element over the first and second types of neural element by selection of at least one of a third value of the stimulation amplitude, a third type of the stimulation polarity, a third value of the pulse width, a third value of the pulse rate, or a third value of the pulse duration for the third stimulation; and

select a one of the third subsets of one or more of the electrodes based, at least in part, on the third responses;

wherein selecting the programming subset of one or more of the electrodes comprises selecting the programming subset of one or more of the electrodes based, at least in part, on the first responses, second responses, and third responses associated with the selected one of the first subsets, the selected one of the second subsets, and the selected one of the third subsets, respectively.

6. The system of claim 1 , wherein receiving the first response comprising receiving the first response from a clinician, patient, or sensor.

7. The system of claim 1 , wherein the first type of neural element and the second type of neural elements are different types of fibers.

8. The system of claim 1 , wherein the first type of neural element and the second type of neural elements are different types of cells.

9. The system of claim 1 , wherein the first type of neural element is large fibers and the second type of neural elements is small fibers that are smaller than the larger fibers.

10. The system of claim 1 , wherein the first type of neural element is aligned, relative to the lead, along a first range of angles and the second type of neural elements is aligned, relative to the lead, along a second range of angles, wherein the first and second ranges do not overlap.

11. The system of claim 10 , wherein the first type of neural element is aligned parallel to the lead and the second type of neural elements is aligned perpendicular to the lead.

12. The system of claim 1 , wherein the first type of neural element is neural fibers and the second type of neural elements is neural cells that are not neural fibers.

13. The system of claim 1 , wherein the first stimulations are monopolar cathodic stimulations and the second stimulations are monopolar anodic stimulations.

14. The system of claim 1 , wherein, for each of the first subsets, the one or more of the electrodes of the first subset is the same as the one or more of the electrodes of a one of the second subsets.

15. A method for programming electrical stimulation of a patient using an implantable electrical stimulation system comprising an implantable pulse generator and a lead having a plurality of electrodes, the method comprising:

receiving a first response for each of a plurality of first stimulations performed using a plurality of different first subsets of one or more of the electrodes of the lead, wherein each of the first stimulations uses one of the first subsets and each of the first subsets is used for at least one of the first stimulations, wherein the first stimulations are each configured to preferentially stimulate a first type of neural element over a second type of neural element by selection of at least one of a first value of a stimulation amplitude, a first type of a stimulation polarity, a first value of a pulse width, a first value of a pulse rate, or a first value of a pulse duration for the first stimulation;

selecting a one of the first subsets of one or more of the electrodes based, at least in part, on the first responses;

receiving a second response for each of a plurality of second stimulations performed using a plurality of different second subsets of one or more of the electrodes, wherein each of the second stimulations uses one of the second subsets and each of the second subsets is used for at least one of the second stimulations, wherein the second stimulations are configured to preferentially stimulate the second type of neural element over the first type of neural element by selection of at least one of a second value of the stimulation amplitude, a second type of the stimulation polarity, a second value of the pulse width, a second value of the pulse rate, or a second value of the pulse duration for the second stimulation;

selecting a one of the second subsets of one or more of the electrodes based, at least in part, on the second responses;

selecting a programming subset of one or more of the electrodes based on the first and second responses associated with the selected one of the first subsets and the selected one of the second subsets, respectively;

receiving direction to program the implantable pulse generator with the programming subset of one or more of the electrodes; and

initiating a signal that provides the implantable pulse generator of the implantable electrical stimulation system with the programming subset of one or more of the electrodes for generating electrical stimulation for the patient through the electrodes of the lead.

16. The method of claim 15 , wherein receiving a first response comprises receiving a first quantitative or qualitative indication of at least one therapeutic effect and receiving a second response comprises receiving a second quantitative or qualitative indication of at least one therapeutic effect.

17. The method of claim 15 , wherein receiving the first response comprises receiving a first quantitative or qualitative indication of at least one therapeutic effect, at least one side-effect, or any combination thereof and receiving the second response comprises receiving a second quantitative or qualitative indication of at least one therapeutic effect, at least one side-effect, or any combination thereof.

18. The method of claim 17 , wherein selecting the programming subset of one or more of the electrodes comprises selecting the programming subset of one or more of the electrodes based on the first and second quantitative or qualitative indications.

19. The method of claim 15 , wherein the processor is further configured to:

receive a third response for each of a plurality of third stimulations performed using a plurality of different third subsets of one or more of the electrodes, wherein each of the third stimulations uses one of the third subsets and each of the third subsets is used for at least one of the third stimulations, wherein the third stimulations are configured to preferentially stimulate a third type of neural element over the first and second types of neural element by selection of at least one of a third value of the stimulation amplitude, a third type of the stimulation polarity, a third value of the pulse width, a third value of the pulse rate, or a third value of the pulse duration for the third stimulation; and

select a one of the third subsets of one or more of the electrodes based, at least in part, on the third responses;

wherein selecting the programming subset of one or more of the electrodes comprises selecting the programming subset of one or more of the electrodes based, at least in part, on the first responses, second responses, and third responses associated with the selected one of the first subsets, the selected one of the second subsets, and the selected one of the third subsets, respectively.

20. The method of claim 15 , wherein receiving the first response comprising receiving the first response from a clinician, patient, or sensor.