Antiviral heterocyclic compounds
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
1. A compound represented by Formula (XXIX-1):
or a pharmaceutically acceptable salt thereof,
wherein R 46 is difluoromethyl, cyclopropyl or 1-fluoro-cyclopropyl; R 47 is hydrogen, chlorine, fluorine or methoxy; R 41 , R 42 , and R 45 are each hydrogen; R 44 is hydrogen, fluorine or chlorine; and R 43 is fluorine or chlorine.
2. The compound of claim 1 , wherein R 46 is cyclopropyl and R 47 is methoxy.
3. The compound of claim 1 , wherein R 46 is difluoromethyl and R 47 is methoxy.
4. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
5. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
6. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
7. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
8. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
9. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
10. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
11. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
12. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
13. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
14. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
15. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
16. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient.
17. A method of treating or preventing an RSV infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.
18. A method of treating or preventing an HMPV infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.