Methods of treating Prader-Willi syndrome
The present invention relates to methods for regulating prohormone convertase (PC1) and compounds and treatments which increase PC1 levels, for treating Prader-Willi Syndrome (PWS).
1. A method for treating Prader-Willi Syndrome (PWS) comprising administering a selective phosphodiesterase 4 inhibitor (PDE4i) to a subject with PWS, in an amount that alleviates, eliminates or prevents one or more symptoms of PWS.
2. The method of claim 1 , wherein the one or more symptoms comprises hyperphagia, reduced metabolic rate, obesity, hypogonadism, decreased growth hormone production, poor muscle tone, reduced stamina, reduced ability to focus, impaired cognition, anxiety, growth failure, reduced conversion of immature hormones to mature and active forms, or diabetes.
3. The method of claim 1 , wherein the one or more symptoms comprises hyperphagia.
4. The method of claim 1 , wherein the one or more symptoms comprises reduced conversion to mature and active forms of one or more of insulin, ghrelin, oxytocin, growth hormone releasing hormone (GHRH), brain-derived neurotrophic factor (BDNF) or gonadotropin.
5. The method of claim 1 , wherein the selective PDE4 inhibitor comprises theophylline, roflimilast, apremilast, ibdulast, GSK356278, or IBMX.
6. The method of claim 1 , wherein the method further comprises administering one or more additional therapeutic agents effective for treating or alleviating one or more symptoms of PWS.
7. The method of claim 1 , wherein the method further comprises administering an oxytocin receptor agonist.
8. The method of claim 1 , wherein the method further comprises administering insulin, an insulin receptor agonist, ghrelin, a ghrelin receptor agonist, growth hormone-releasing hormone (GHRH), a GHRH receptor agonist, alpha-melanocyte stimulating hormone (alpha-MSH), an alpha-MSH receptor agonist, oxytocin, an oxytocin receptor agonist, orexin, an orexin receptor agonist, Brain-derived neurotrophic factor (BDNF), a BDNF receptor agonist, vasopressin, a vasopressin receptor agonist, Neuropeptide Y (NPY), an NPY receptor agonist, Agouti-related protein (AGRP), an AGRP receptor agonist, gonadotropin, a gonadotropin receptor against, or combinations thereof.