Inhibitors of positive strand RNA viruses
Methods of treating a disease caused by a positive strand RNA virus. The methods include administering to a subject in need thereof an effective amount of a compound of Formula I or Formula II.
1. A method for inhibiting a positive strand RNA virus, the method comprising:
identify a subject infected with the positive strand RNA virus, and
administering to the subject an effective amount of a compound of Formula II:
wherein
each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 , independently, is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, nitro, cyano, —OR a , —OC(O)R a , —C(O)OR a , —NR a R b , —NR a C(O)R b , or —C(O)NR a R b , each of R a and R b , independently, being H, alkyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl;
X Y, together, is C(R′)(R″)—N or CR′═N + , in which R′ is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, nitro, or cyano, and R″ is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, nitro, cyano, —OR c , or —OC(O)R c , R c being H, alkyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl;
A is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
is a single bond or a double bond; and
the positive strand RNA virus is a Zika virus or a Dengue virus.
2. The method of claim 1 , wherein each of R 1 , R 4 , R 5 , and R 8 is H; R 2 is H or alkoxy; each of R 3 , R 6 , and R 7 , independently, is alkoxy; R 9 is H or alkyl, R 10 is H or OH; X is CH 2 ; Y is N; A is alkyl; and is a single bond.
3. The method of claim 2 , wherein the compound of Formula II is selected from the group consisting of Compound 2, Compound 3, Compound 5, Compound 7, Compound 8, and Compound 9: