Polymeric mesh products, method of making and use thereof

1. A single-layer polymeric mesh consisting of one layer having essentially identical first and second sides, the one layer consisting of two fiber types co-knit to form single layer;

a) wherein the first fiber type consists of an absorbable polymeric multifilament fiber, the absorbable polymeric multifilament fiber providing from 30% to 60% by weight of the single-layer polymeric mesh; and

b) the second fiber type consists of a non-absorbable synthetic monofilament polymeric fiber, the non-absorbable synthetic monofilament polymeric fiber selected from polyethylene with a denier of 60-150 g/9000 m or polypropylene with a denier of 130-180 g/9000 m, wherein said non-absorbable synthetic monofilament polymeric fiber has an ultimate elongation of greater than 30%;

wherein said absorbable polymeric multifilament fiber is warp knit with said non-absorbable synthetic monofilament fiber to form said single layer polymeric mesh, where the absorbable fiber is knit in a 2 bar marquisette pattern and the non-absorbable fiber is knit in a 2 bar sand-fly net pattern with all guide bars for each pattern threaded 1-in and 1-out;

wherein said absorbable fibers are interlaced with said non-absorbable fibers and at least partly traverses the non-absorbable fibers such that the absorbable fibers restrict uniaxial and multiaxial movement by said non-absorbable fibers; and

wherein said single layer warp-knit mesh has at least two different strength profiles including an initial stiff phase prior to degradation of the absorbable polymeric multifilament fiber and a later extensible phase that results after degradation of the absorbable polymeric multifilament fiber.

2. The single-layer polymeric mesh of claim 1 , wherein the non-absorbable synthetic monofilament polymeric fiber facilitates uniaxial and multiaxial deformation subsequent to a substantial loss of mechanical properties contributed by the absorbable polymeric multifilament fiber to the single-layer polymeric mesh.

3. The single-layer polymeric mesh of claim 1 , wherein said single-layer polymeric mesh provides structural stability to developing neotissue at an implantation site.

4. The single-layer polymeric mesh of claim 1 , wherein said single-layer polymeric mesh has long-term force-extensional characteristics compatible with surrounding tissues at an implantation site.

5. The single-layer polymeric mesh of claim 1 , wherein said absorbable polymeric multifilament fiber substantially degrades in vivo at an implantation site in a period of 1-12 weeks.

6. The single-layer polymeric mesh of claim 1 , wherein said absorbable polymeric multifilament fiber comprises a polyaxial, segmented biodegradable copolyester fiber.

7. The single-layer polymeric mesh of claim 6 , wherein said polyaxial, segmented biodegradable copolyester fiber comprises a glycolide/l-lactide/trimethylene carbonate copolymer.

8. The single-layer polymeric mesh of claim 1 , wherein said absorbable polymeric multifilament fiber comprises a homopolymer of polydioxanone.

9. The single-layer polymeric mesh of claim 1 , wherein said absorbable polymeric multifilament fiber comprises a PEG/glycolide/l-lactide copolymer fiber.

10. The single-layer polymeric mesh of claim 1 , wherein said absorbable polymeric multifilament fiber has a denier range of 25-200 g/9000 m.

11. The single-layer polymeric mesh of claim 1 , wherein said absorbable polymeric multifilament fiber has an ultimate elongation that is equal to or less than an ultimate elongation of said non-absorbable synthetic monofilament polymeric fiber.

12. The single-layer polymeric mesh of claim 1 , wherein said single-layer polymeric mesh has an initial weight, an initial area weight ranging from about 70 to 110 g/m 2 , and a long-term residual weight of about 40-70% of the initial weight.

13. The single-layer polymeric mesh of claim 1 , wherein said single-layer polymeric mesh has a total porosity within a range of 30-40% with an initial average pore size of about 1 mm and a long-term average pore size of about 2-3 mm.

14. The single-layer polymeric mesh of claim 1 , wherein the non-absorbable synthetic monofilament polymeric fiber comprises polyethylene.

15. The single-layer polymeric mesh of claim 1 , wherein the non-absorbable synthetic monofilament polymeric fiber comprises polypropylene.

16. The single-layer polymeric mesh of claim 1 , wherein the non-absorbable synthetic monofilament polymeric fiber has an ultimate elongation of 40-80%.

17. The single-layer polymeric mesh of claim 1 , having a thickness in a range of 0.1 mm-2 mm.