Liquid chromatograph with improved defect elimination
A liquid chromatograph is presented which enables automatic resolution of a liquid sending failure when the liquid sending failure caused by a liquid sending pump occurs, and execution of a new analysis with good reproducibility after the liquid sending failure is resolved. The liquid sending failure can be automatically resolved by a purging operation. A sample remaining in the analysis flow path is washed away by a non-injection analysis after the liquid sending failure is resolved, and a new analysis can be executed with good reproducibility.
1. A liquid chromatograph comprising:
a liquid sending pump that sends a mobile phase;
an analysis flow path having a separation column for separating a sample into components and a detector for detecting sample components obtained by separation in the separation column;
a pressure sensor that detects a liquid sending pressure applied by the liquid sending pump;
a sample injector for injecting a sample into the analysis flow path;
a switcher for switching a state between the liquid sending pump and the analysis flow path to a connection state or a disconnection state;
a liquid sending failure detector configured to compare a variation range of the liquid sending pressure detected by the pressure sensor with a preset threshold value, and detect a liquid sending failure caused by the liquid sending pump when the variation range of the liquid sending pressure exceeds the threshold value;
an analysis operation executer configured to control operations of the liquid sending pump, the sample injector and the switcher, and execute an analysis by putting the state between the liquid sending pump and the analysis flow path in a connection state and injecting a sample into the analysis flow path, as a scheduled analysis in regard to all of samples scheduled to be analyzed in a preset analysis schedule;
a purge operation executer, when a liquid sending failure is detected by the liquid sending failure detector during a sample analysis, configured to interrupt a sample analysis in execution, put the state between the liquid sending pump and the analysis flow path in a disconnection state and execute a purge operation of sending a liquid mobile using the liquid sending pump at a flow rate higher than a flow rate during the analysis for a preset purge time;
a confirming operation executer configured to execute a confirming operation of confirming whether a liquid sending failure is detected by the liquid sending failure detector after the purge operation ends; and
a non-injection analysis executer, when a liquid sending failure is not detected by the liquid sending failure detector in the confirming operation, configured to execute a non-injection analysis in which a mobile phase is sent into the analysis flow path by the liquid sending pump under a condition that enables removal of a sample in the analysis flow path, wherein
the analysis operation executer is configured to restart the scheduled analysis after the non-injection analysis is executed.
2. The liquid chromatograph according to claim 1 , wherein
the non-injection analysis executer is configured to send a mobile phase using the liquid sending pump into the analysis flow path under a same condition as a condition for an analysis that is executed immediately before the purge operation in the non-injection analysis.
3. The liquid chromatograph according to claim 1 , wherein
the purge operation executer is configured to execute the purge operation again when a liquid sending failure is detected by the liquid sending failure detector in the confirming operation.
4. The liquid sending chromatograph according to claim 3 , wherein
the analysis operation executer is configured to end the scheduled analysis when a liquid sending failure is detected by the liquid sending failure detector in the confirming operation after the purge operation is executed a predetermined number of times corresponding to a predetermined count.
5. The liquid chromatograph according to claim 4 , comprising a purge count setter configured to set the predetermined count for the purge operation based on information input by a user.
6. The liquid chromatograph according to claim 1 , comprising a purge time setter configured to set the purge time based on information input by a user.
7. The liquid chromatograph according to claim 1 , wherein
the analysis operation executer is configured to end the scheduled analysis when a count of liquid sending failures detected by the liquid sending failure detector during the scheduled analysis exceeds a preset allowable count.
8. The liquid chromatograph according to claim 1 , wherein
the non-injection analysis includes sending a mobile phase into the analysis flow path using the liquid sending pump under a same condition as a condition for a sample analysis without injection of a sample.