Method for improving mitophagy in subjects
The invention provides a compound of formula (I) wherein: A, B, C, D, W, X, Y and Z are each independently selected from H and OH; or a salt thereof; for use in the treatment and/or prophylaxis of a condition, disease or disorder in a subject, wherein the compound or salt is orally administered to a subject in a daily amount of from 2.8 to 6.6 mmol per day, over a period of at least 21 days. Also are provided are the compound of formula (I) for use in increasing mitophagy and/or autophagy, maintaining and/or improving muscle function and administration as a dietary, nutritional and/or health supplement.
1. A method of improving mitochondrial function or muscle function or muscle performance, comprising orally administering to a human in need thereof urolithin A or a salt thereof;
wherein the urolithin A or a salt thereof is administered at 1000 mg/day, over a period of 28 days; and the urolithin A or salt thereof is administered in the form of a soft gel capsule which further comprises lecithin, medium chain triglycerides (MCT), and glycerol monostearate.
2. The method of claim 1 , wherein the urolithin A or salt thereof is administered once per day.
3. The method of claim 1 , wherein the urolithin A or salt thereof is administered twice per day.
4. The method of claim 1 , wherein mitochondrial function is improved.
5. The method of claim 1 , wherein muscle function or muscle performance is improved.
6. The method of claim 4 , wherein the urolithin A or salt thereof is administered once per day.
7. The method of claim 4 , wherein the urolithin A or salt thereof is administered twice per day.
8. The method of claim 5 , wherein the urolithin A or salt thereof is administered once per day.
9. The method of claim 5 , wherein the urolithin A or salt thereof is administered twice per day.
10. A method of improving mitochondrial function or muscle function or muscle performance, comprising orally administering to a human in need thereof urolithin A or a salt thereof;
wherein the urolithin A or a salt thereof is administered at 1000 mg/day, over a period of 28 days; the urolithin A or salt thereof is administered in the form of a soft gel capsule which further comprises lecithin, medium chain triglycerides (MCT), and glycerol monostearate; and the human is elderly.
11. The method of claim 10 , wherein the urolithin A or salt thereof is administered as a dietary, nutritional or health supplement.
12. The method of claim 10 , wherein the urolithin A or salt thereof is administered once per day.
13. The method of claim 10 , wherein the urolithin A or salt thereof is administered twice per day.
14. The method of claim 10 , wherein mitochondrial function is improved.
15. The method of claim 10 , wherein muscle function or muscle performance is improved.
16. The method of claim 14 , wherein the urolithin A or salt thereof is administered once per day.
17. The method of claim 14 , wherein the urolithin A or salt thereof is administered twice per day.
18. The method of claim 15 , wherein the urolithin A or salt thereof is administered once per day.
19. The method of claim 15 , wherein the urolithin A or salt thereof is administered twice per day.