IP Library › Granted Patent US 11,986,505
Granted Patent B2
US 11,986,505 · App. 18/299,810 · Granted May 21, 2024

Methods of treating endometriosis and other noncancer gynecological disorders with hemp extract

Inventors: Alexandra M. Capano (Philadelphia, PA); Pradeep Singh Tanwar (Fletcher, AU); Alex Nance (Georgetown, KY)
Assignees: Ecofibre USA Inc.; The University of Newcastle
A61K36/185A61K31/015A61K31/045A61K31/05A61K31/352A61K31/353A61K31/60A61P35/00
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Quick Facts
Patent No.
US 11,986,505
App. No.
18/299,810
Granted
May 21, 2024
Kind
B2
Abstract

A method for treating a noncancerous gynecological disorder comprising: administering to a patient and effective amount of composition comprising a cannabis extract comprising cannabidiol (CBD) wherein the composition is preferably administered in a mucosal form, such as intravaginally.

Claims (21)

1. A composition for treatment of a noncancerous gynecological disorder (NCGD) selected from the group consisting of: endometriosis, an ovarian endometrioma, a deep endometriosis, dysmenorrhea, and fibroids; wherein the composition comprises between 1% and 99% by weight of a cannabis extract (CE) and wherein the CE of the composition comprises:

a. an extract selected from the group consisting of: a full spectrum hemp extract (FSHE), a broad spectrum hemp extract (BSHE), a cannabidiol (CBD) isolate, and combinations thereof;

b. a carrier at between 1% and 99% by weight of the composition;

c. one or more excipients at between 1% and 50% by weight of the composition; and

d. the CE formulated for administration oromucosally and intravaginally as two separate doses.

2. The composition of claim 1 wherein the composition is acidic with a pH between 3.5 and 6.

3. The composition of claim 1 wherein the CE comprises between 10 mg and 4,250 mg of cannabidiol (CBD).

4. The composition of claim 1 wherein the composition comprises at least one additional compound selected from the group consisting of: a terpene, a polyphenol, an essential fatty acid, a phytonutrient, and combinations thereof; and wherein the at least one additional compound makes up between 0.1% and 50% by weight of the composition.

5. The composition of claim 1 wherein the composition comprises an oil or a fat as a carrier.

6. The composition of claim 1 wherein the composition further comprises at least one additional cannabinoid at between 0.1% and 10% weight percentage of the composition wherein the at least one additional cannabinoid is selected from the group consisting of: Δ-9-tetrahydrocannabinol (Δ 9 -THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), Δ-8-tetrahydrocannabinol (Δ 8 -THC), cannabichromene (CBC), cannabichromene acid (CBCA), cannabigerol (CBG), cannabigerol acid (CBGA), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabinol (CBN), cannabicyclol (CBL), and combinations thereof.

7. A composition for intravaginal application for treatment of a noncancerous gynecological disorder (NCGD) selected from the group consisting of:

endometriosis, an ovarian endometrioma, a deep endometriosis, dysmenorrhea, and fibroids; wherein the composition comprises between 1% and 99% by weight of a cannabis extract (CE) and wherein the CE of the composition comprises:

a. an extract selected from the group consisting of: a full spectrum hemp extract (FSHE), a broad spectrum hemp extract (BSHE), a cannabidiol (CBD) isolate, and combinations thereof;

b. between 0.1% and 10% of a cannabidiolic acid (CBDA) isolate;

c. a carrier at between 1% and 99% by weight of the composition; and

d. one or more excipients at between 1% and 50% by weight of the composition.

8. The composition of claim 7 wherein the composition is acidic with a pH between 3.5 and 6.

9. The composition of claim 7 wherein the CE comprises between 10 mg and 4,250 mg of cannabidiol (CBD).

10. The composition of claim 7 wherein the composition comprises at least one additional compound selected from the group consisting of: a terpene, a polyphenol, an essential fatty acid, a phytonutrient, and combinations thereof; and wherein the at least one additional compound makes up between 0.1% and 50% by weight of the composition.

11. The composition of claim 7 wherein the composition comprises an oil or a fat as a carrier.

12. The composition of claim 7 wherein the composition further comprises at least one additional cannabinoid at between 0.1% and 10% weight percentage of the composition wherein the at least one additional cannabinoid is selected from the group consisting of: Δ-9-tetrahydrocannabinol (Δ 9 -THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), Δ-8-tetrahydrocannabinol (Δ 8 -THC), cannabichromene (CBC), cannabichromene acid (CBCA), cannabigerol (CBG), cannabigerol acid (CBGA), cannabidivarin (CBDV), cannabinol (CBN), cannabicyclol (CBL), and combinations thereof.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 3, 2025
From: ECOFIBRE USA, INC.
To: DOVE INNOVATION PTY LIMITED
Reel/Frame 072141/0535 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 2, 2023
From: ECOFIBRE LIMITED
To: ECOFIBRE USA INC.
Reel/Frame 064464/0611 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 5, 2023
From: CAPANO, ALEXANDRA M.
To: ECOFIBRE LIMITED
Reel/Frame 063546/0740 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 5, 2023
From: NANCE, ALEX
To: ECOFIBRE LIMITED
Reel/Frame 063546/0786 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 5, 2023
From: TANWAR, PRADEEP SINGH
To: THE UNIVERSITY OF NEWCASTLE
Reel/Frame 063546/0831 →
Continuity (5)
Division 18050023 · Oct 26, 2022
Provisional Application 63263026 · Oct 26, 2021
Provisional Application 63263020 · Oct 26, 2021
Provisional Application 63263022 · Oct 26, 2021
Related Publication 20230241146A1 · Aug 3, 2023