Co-crystal of sorafenib derivatives and process for preparation thereof
The present disclosure provides compounds for the inhibition of soluble epoxide hydrolase and associate disease conditions, as well as a method of treating or preventing disorders in a subject by inhibition of soluble epoxide hydrolase.
1. A co-crystal compound having Formula (II):
or a stereoisomer thereof,
wherein:
A is CH or N;
n is an integer selected from 0-5;
R 1 is selected from the group consisting of H, halogen, hydroxyl, N 3 , NH 2 , NO 2 , CF 3 , OCF 3 , C 1-10 alkyl, substituted C 1-10 alkyl, C 1-10 alkoxy, substituted C 1-10 alkoxy, acyl, acylamino, acyloxy, acyl C 1-10 alkyloxy, amino, substituted amino, aminoacyl, aminocarbonyl, C 1-10 alkyl, aminocarbonylamino, aminodicarbonylamino, aminocarbonyloxy, and aminosulfonyl;
X is an integer selected from 3-20;
the amino acid is selected from the group consisting of glycine, L-proline, L-asparagine, L-aspartic acid, L-glutamine, L-glutamic acid, L-lysine, L-arginine, L-histidine, L-serine, L-threonine, L-cysteine, L-methionine, L-phenylalanine, L-tyrosine, L-tryptophan, L-alanine, L-valine, L-leucine, L-isoleucine, D-asparagine, D-aspartic acid, D-glutamine, D-glutamic acid, D-histidine, D-arginine, D-cysteine, D-serine, D-threonine, D-lysine, D-methionine, D-phenylalanine, D-alanine, D-valine, D-leucine, D-isoleucine and D-proline, D-tyrosine, D-tryptophan, and their derivatives with protecting groups.
2. The co-crystal compound of claim 1 , with the structure of Formula (B)
3. The co-crystal compound of claim 2 , with the structure of Formula (C)
4. The co-crystal compound of claim 1 , wherein the amino acid is L-arginine.
5. The co-crystal compound of claim 1 , which is soluble in a pharmaceutically acceptable aqueous vehicle to form an orally deliverable solution.
6. A pharmaceutical composition comprising the co-crystal compound of claim 1 having one or more pharmaceutically acceptable carriers, excipients and diluents.
7. The pharmaceutical composition of claim 6 , which is in a form of a rapidly disintegrating tablet.
8. The pharmaceutical composition of claim 6 , wherein the pharmaceutically acceptable excipient is selected from the group consisting of surfactants, solubilizers, disintegrants, microcrystalline cellulose, starch, sodium starch glycolate, crosslinked carboxy methyl cellulose sodium, crosslinked PVP, pigments, flavors, fillers, lubricants, glidants, preservatives, thickening agents, buffering agents, pH modifiers and any combination thereof.
9. A method of treating or preventing a disease or disorder in a subject by inhibiting soluble epoxide hydrolase (sEH), the method comprising administering to the subject a pharmaceutical composition comprising: (a) a compound of claim 1 ; and (b) a pharmaceutically acceptable carrier.
10. A method of treating or preventing a disease or disorder in a subject by inhibiting soluble epoxide hydrolase (sEH), the method comprising: (a) dissolving, in a pharmaceutically acceptable aqueous vehicle, a compound of claim 1 to form an aqueous pharmaceutical composition; and (b) administering the pharmaceutical composition to the subject.
11. The method of claim 9 , wherein the compound is a co-crystal of EC1728 and L-arginine.
12. The method of claim 9 , wherein the pharmaceutical composition is administered orally or intravenously.
13. The method of claim 9 , wherein the disease or disorder is selected from the group consisting of renal, hepatic, or pulmonary hypertension, chronic pain, acute pain, inflammation, renal inflammation, hepatic inflammation, vascular inflammation, and lung inflammation, adult respiratory distress syndrome, diabetic complications, end stage renal disease, Raynaud syndrome, arthritis, myocardial infarction, stroke, ischemia, Alzheimer's disease, Parkinson's disease, Gehrig's disease (Amyotrophic Lateral Sclerosis), Huntington's disease, Multiple Sclerosis, senile dementia, subcortical dementia, arteriosclerotic dementia, AIDS-associated dementia, other dementias, cerebral vasculitis, epilepsy, Tourette's syndrome, Guillain Bane Syndrome, Wilson's disease, Pick's disease, encephalitis, encephalomyelitis, meningitis, prion diseases, cerebellar ataxias, cerebellar degeneration, spinocerebellar degeneration syndromes, Friedrich's ataxia, ataxia telangiectasia, spinal dysmyotrophy, progressive supranuclear palsy, dystonia, muscle spasticity, tremor, retinitis pigmentosa, striatonigral degeneration, mitochondrial encephalomyopathies and neuronal ceroid lipofuscinosis.
14. The method of claim 9 , wherein the subject is a human or non-human mammal.
15. The method of claim 9 , wherein the subject is an equine and the disease or disorder is pain, inflammation or laminitis.
16. A process for preparing a compound of claim 1 , comprising: (a) dissolving a sorafenib derivative and an amino acid in a mixture of ethanol and water to obtain a solution; and (b) removing the water and ethanol to obtain a co-crystal.
17. A process for preparing a compound of claim 1 , comprising: (a) adding a sorafenib derivative in a dried form to a solution of an amino acid and water and washing it with ethanol to complete dissolution; and (b) removing the water and ethanol to obtain a co-crystal.