Neurostimulator and method for delivering a stimulation in response to a predicted or detected neurophysiological condition
There is provided a neurostimulator and method for delivering to a subject a stimulation in response to a predicted or detected condition. The neurostimulator including: a power circuit for providing electrical power to the neurostimulator; a recording array having a plurality of electrodes for recording a plurality of neurophysiological signals corresponding to a plurality of sites of the subject; a signal processor configured to: determine a phase synchrony among the neurophysiological signals; and associate selected phase synchrony calculations with the prediction or detection of a neurological or neurophysiological condition; and one or more stimulators for delivering to the subject a stimulation in response to the predicted or detected condition.
1. A neurostimulator, the neurostimulator implantable or wearable on a subject, the neurostimulator comprising:
a power circuit for providing electrical power to the neurostimulator;
a recording array having a plurality of electrodes for recording a plurality of neurophysiological signals corresponding to a plurality of sites of the subject;
a signal processor configured to:
determine a phase synchrony among the neurophysiological signals; and
associate selected phase synchrony calculations with the prediction or detection of a neurological or neurophysiological condition; and
one or more stimulators for delivering to the subject a stimulation in response to the predicted or detected condition,
wherein the stimulation comprises generating and applying an arbitrary current-mode waveform to a subset of the stimulators and wherein the arbitrary current-mode waveform is generated by a waveform generator that provides the signal and its derivative for use in the calculation of phase synchrony.
2. The neurostimulator of claim 1 , wherein the responsive stimulation comprises any one or more of an electrical charge, electrical current, electrical voltage, optical signal, chemical agent and temperature controlling signal.
3. The neurostimulator of claim 1 , wherein the power circuit comprises a wireless inductive link permitting a receiver coil to be located remotely from the neurostimulator.
4. The neurostimulator of claim 1 , wherein the recording array records signals by electroencephalography, electrocardiography, electromyography, or a combination thereof.
5. The neurostimulator of claim 1 , wherein the recording array is configured to record either current or voltage.
6. The neurostimulator of claim 1 , wherein the neurostimulator further comprises a digitizer, and the recording array is linked to the digitizer for digitizing the neurophysiological signals.
7. The neurostimulator of claim 6 , wherein the digitizer comprises an in-channel ΔΣ or Δ 2 Σ neural analog-to-digital converter.
8. The neurostimulator of claim 6 , wherein the signal processor is a digital signal processor.
9. The neurostimulator of claim 1 , wherein the recording array comprises sixty four channels.
10. The neurostimulator of claim 1 , wherein the recorded signals are modulated by a 1-bit waveform, wherein the waveform is 1 when sin(ω o t)/cos(ω o t)>1 and 0 when sin(ω o t)/cos(ω o t)<0.
11. The neurostimulator of claim 1 , wherein the arbitrary current-mode waveform is generated with a spatio-temporal profile determined specifically for the subject.
12. The neurostimulator of claim 11 , wherein the determination of the spatio-temporal profile comprises a one-sided simultaneous perturbation stochastic approximation (SPSA), wherein for any particular stimulation the one-sided SPSA applies exactly one sampling of the phase synchrony to compute a gradient approximation.
13. The neurostimulator of claim 1 , wherein the waveform generator provides an analog in-channel multiplier for the recording array.