IP Library › Granted Patent US 11,998,383
Granted Patent B2
US 11,998,383 · App. 16/927,911 · Granted Jun 4, 2024

Enhanced stethoscope device and method for blood pressure measurement via plurality of ultrasound transducers and optical sensors to determine time series blood values using autoencoders

Inventors: Aditya Rajagopal (Orange, CA); Alaina Ann Brinley Rajagopal (Orange, CA)
Assignee: California Institute of Technology
A61B7/04A61B5/0022A61B5/02055A61B5/7257A61B5/726A61B5/7264A61B8/4416A61B8/4477G01S15/8952G01S15/899A61B5/021A61B5/0816A61B5/14532A61B5/14542A61B5/7253A61B5/742A61B8/02A61B8/06A61B8/085A61B8/4209A61B8/461A61B8/565A61B2560/0214
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Quick Facts
Patent No.
US 11,998,383
App. No.
16/927,911
Granted
Jun 4, 2024
Kind
B2
Abstract

An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.

Claims (26)

1. An enhanced stethoscope device comprising:

a first ultrasonic transducer for transmitting a first ultrasonic imaging signal to a blood vessel of a subject and receiving a second ultrasonic imaging signal from the blood vessel;

a second ultrasonic transducer for transmitting a third ultrasonic imaging signal to the blood vessel and receiving a fourth ultrasonic imaging signal from the blood vessel; and

an optic sensor directed toward the blood vessel;

wherein the blood pressure measurement device is configured to:

reconstruct, using the second ultrasonic imaging signal and the fourth ultrasonic imaging signal, an ultrasonic image;

obtain a first time series of sensor values associated with one or more signals received by the first ultrasonic transducer;

obtain a second time series of sensor values associated with one or more signals received by the second ultrasonic transducer;

obtain a third time series of sensor values associated with one or more signals received by the optic sensor;

pass the first time series of sensor values, the second time series of sensor values, and the third time series of sensor values to an autoencoder;

determine, based at least on the first time series of sensor values, the second time series of sensor values, and the third time series of sensor values, using the autoencoder, a physiometric parameter associated with the subject; and

correlate the second ultrasonic imaging signal received from the blood vessel and a first optical signal received from the blood vessel to determine a blood pressure,

wherein a first velocity measurement of a blood bolus in the blood vessel is obtained using the first ultrasonic transducer and the second ultrasonic transducer, and a second velocity measurement of the blood bolus in the blood vessel is obtained by the optic sensor.

2. The enhanced stethoscope device of claim 1 , wherein the blood pressure measurement device is configured to correlate the first velocity measurement and the second velocity measurement to determine a blood pressure.

3. The blood pressure measurement device of claim 1 , wherein the optic sensor comprises a light source for transmitting a second optical signal to the blood vessel, and a light detector for receiving the first optical signal from the blood vessel.

4. The enhanced stethoscope measurement device of claim 3 , wherein the second optical signal is scattered, dispersed, or reflected from the blood bolus to form the first optical signal.

5. The enhanced stethoscope device of claim 3 , wherein the light source comprises a light emitting diode (LED).

6. The enhanced stethoscope device of claim 3 , wherein the light source comprises a laser.

7. The enhanced stethoscope device of claim 3 , wherein the light detector comprises a photodiode.

8. The enhanced stethoscope device of claim 3 , wherein the light detector comprises a camera.

9. The enhanced stethoscope device of claim 3 , wherein the optical sensor measures a blood oxygenation saturation level.

10. The enhanced stethoscope device of claim 1 , wherein the blood pressure measurement device is further configured to correlate the second ultrasonic imaging signal with the fourth ultrasonic imaging signal.

11. The enhanced stethoscope device of claim 1 , wherein the blood pressure measurement device is further configured to correlate the fourth ultrasonic imaging signal with the second ultrasonic imaging signal.

12. The enhanced stethoscope device of claim 1 , wherein the first and second ultrasonic transducers are configured to transmit and receive simultaneously with one another.

13. The enhanced stethoscope device of claim 12 , wherein the first and second ultrasonic imaging signals correspond to a first frequency, and the third and fourth ultrasonic imaging signals correspond to a second frequency different from the first frequency.

14. The enhanced stethoscope device of claim 1 , wherein the first and second ultrasonic imaging signals correspond to a first frequency, and the third and fourth ultrasonic imaging signals correspond to a second frequency different from the first frequency.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 24, 2020
From: RAJAGOPAL, ADITYA; RAJAGOPAL, ALAINA ANN BRINLEY
To: CALIFORNIA INSTITUTE OF TECHNOLOGY
Reel/Frame 053865/0258 →
Continuity (5)
Continuation 16689427 · Nov 20, 2019
Continuation 16038070 · Jul 17, 2018
Continuation 15678789 · Aug 16, 2017
Provisional Application 62376300 · Aug 17, 2016
Related Publication 20210169441A1 · Jun 10, 2021
Cited By (1)
US 12,484,809