Tetrahydropyridopyrimidine pan-KRas inhibitors
The present invention relates to compounds that inhibit at least one of KRas wild type, KRas G12A, KRas G12C, KRas G12D, KRas G12R, KRas G12S, KRas G12V, KRas G13D and KRas Q61H, pharmaceutical compositions comprising the compounds and methods of use therefor.
1. A compound selected from:
and a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
5. A pharmaceutical composition comprising a therapeutically effective amount of a compound of any one of claim 1 , 3 , 4 , or 2 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.