Inhibitors of RSV replication and applications thereof
Disclosed herein are compounds having antiviral activity, and, in particular, an inhibitory activity on the replication of Respiratory Syncytial Virus (RSV). Druggable target sites, including Px, in the RSV N protein are disclosed, as well as compounds targeting Px. The compounds can be used to treat patients with RSV infection.
1. A compound having the formula:
or a pharmaceutically acceptable salt thereof,
wherein:
X 1 is N;
X 2 is N;
Y is a phenyl group having the formula:
wherein R y2 , R y3 , R y4 , and R y5 are each hydrogen, and R y1 is selected from F, Cl, Br, I, and CF 3 ;
R 1 is hydrogen;
R 2 is selected C(O)OR 2a and C(O)N(R 2a ) 2 , wherein R 2a is in each case independently selected from , C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, aryl, C 1-8 heteroaryl, C 3-8 cycloalkyl, or C 1-8 heterocyclyl;
R 3 is hydrogen.
2. The compound according to claim 1 , wherein R y1 is CF 3 .
3. The compound according to claim 1 , wherein R 2 is C(O)OR 2a .
4. The compound according to claim 1 , wherein R 2 is C(O)OR 2a and R 2a is C 1-8 alkyl.
5. The compound according to claim 3 , wherein R y1 is Cl.
6. The compound according to claim 1 , wherein R y1 is F.
7. A pharmaceutical composition comprising the compound of claim 1 .
8. A method of treating a patient infected with RSV, comprising administering the compound of claim 1 .
9. The method of claim 8 , further comprising administering adjunctively at least one other active compound.