Hydrogen-enhanced transdermal system
A hydrogen-enhanced drug delivery system for hydrogen-assisted transdermal delivery of a therapeutic agent is provided. The system includes a hydrogen-generating compartment comprising at least one dry chemical. Addition of an activator, such as a liquid composition, from within or outside of the system, causes the dry chemical(s) to generate molecular hydrogen (H 2 ) within the system. The molecular hydrogen passes through a skin-contacting surface of the system, which is permeable to hydrogen and not permeable to the dry chemical(s) and the liquid composition, and enhances the release of the therapeutic agent from the system as H 2 is delivered to the subject's body. The H 2 can also enhance the therapeutic effect of the therapeutic agent.
1. A method of delivering a therapeutic agent to a target area of a subject's skin, the method comprising:
applying a hydrogen-enhanced drug delivery system to the target area of the subject's skin by positioning a body comprising a skin-contacting surface of the system onto the target area, the body of the hydrogen-enhanced drug delivery system having enclosed therein:
1) a first portion comprising an aluminum powder, Ca(OH) 2 , and one or more biopolymers;
2) a second portion comprising the therapeutic agent; and
3) a third portion configured to releasablv store a liquid activator or to receive a liquid activator through an opening,
wherein the skin-contacting surface is at least partially hydrogen-permeable and is not permeable to the aluminum powder, Ca(OH) 2 , one or more biopolymers, and the liquid activator; and
causing the liquid activator to at least partially contact the aluminum powder, Ca(OH) 2 , and the one or more biopolymers such that the aluminum powder, Ca(OH) 2 , and the one or more biopolymers interacts with the liquid activator to cause generation of molecular hydrogen that is released from the system through the skin-contacting surface thereby facilitating penetration of the therapeutic agent through the subject's skin.
2. The method of claim 1 , wherein the second portion is a skin-contacting surface of the body of the hydrogen-enhanced drug delivery system.
3. The method of claim 2 , wherein the skin-contacting surface of the body of the hydrogen-enhanced drug delivery system has an adhesive mixed with the therapeutic agent.
4. The method of claim 2 , wherein the therapeutic agent is infused on the skin-contacting surface.
5. The method of claim 1 , wherein the one or more biopolymers comprises xanthan gum, microcrystalline cellulose, maltodextrin, saccharine, or agar-agar.
6. The method of claim 1 , wherein the third portion comprises a cover to seal the opening after delivering the liquid activator.
7. The method of claim 1 , wherein the liquid activator comprises one or more of water, a water suspension of calcium hydroxide, a water solution of sodium chloride and copper (II) sulfate, and a suitable acid or base.
8. The method of claim 1 , further comprising delivering the liquid activator through the opening before the hydrogen-enhanced drug delivery system is applied to the target area of the subject's skin; or wherein delivering the liquid activator is performed after the hydrogen-enhanced drug delivery system is applied to the target area of the subject's skin.
9. The method of claim 1 , wherein the subject has a disease, disorder, or condition of the integumentary system, and the method causes a treatment and/or mitigation of the disease, disorder, or condition of the integumentary system.
10. A method of delivering a therapeutic agent to a target area of a subject's skin, the method comprising:
applying a hydrogen-enhanced drug delivery system to the target area of the subject's skin by positioning a body comprising a skin-contacting surface of the system onto the target area, the body of the hydrogen-enhanced drug delivery system having enclosed therein:
1) a first portion comprising an aluminum powder, Ca(OH) 2 , microcrystalline cellulose, and xanthan gum;
2) a second portion comprising the therapeutic agent; and
2) a third portion configured to releasably store a liquid activator or to receive a liquid activator through an opening,
wherein the skin-contacting surface is at least partially hydrogen-permeable and is not permeable to the aluminum powder, Ca(OH) 2 , microcrystalline cellulose, xanthan gum, and the liquid activator; and
causing the liquid activator to at least partially contact the aluminum powder, Ca(OH) 2 , microcrystalline cellulose, and xanthan gum to cause generation of molecular hydrogen that is released from the system through the skin-contacting surface thereby facilitating penetration of the therapeutic agent through the subject's skin.
11. The method of claim 1 , wherein the therapeutic agent comprises herbs, herbal-derived compounds, oils, essential oils, Aloe vera, Hippophae rhamnoides , sea buckthorn, Angelica sinensis, Catharanthus roseus, Vinca rosea, Calendula officinalis , marigold, Sesamum indicum, Morinda citrifolia , noni, Camellia sinensis, Rosmarinus officinalis L ., rosemary, primrose oil, tea tree oil, propolis, honey, or honey-containing agents.
12. The method of claim 1 , comprising causing the liquid activator to be to be released from the third portion by applying pressure onto the third portion.
13. The method of claim 10 , wherein the second portion is a skin-contacting surface of the body of the hydrogen-enhanced drug delivery system.
14. The method of claim 13 , wherein the skin-contacting surface of the body of the hydrogen-enhanced drug delivery system has an adhesive mixed with the therapeutic agent.
15. The method of claim 13 , wherein the therapeutic agent is infused on the skin-contacting surface.
16. The method of claim 10 , wherein the third portion comprises a cover to seal the opening after delivering the liquid activator.
17. The method of claim 10 , wherein the liquid activator comprises one or more of water, a water suspension of calcium hydroxide, a water solution of sodium chloride and copper (II) sulfate, and a suitable acid or base.
18. The method of claim 10 , further comprising delivering the liquid activator through the opening before the hydrogen-enhanced drug delivery system is applied to the target area of the subject's skin; or wherein delivering the liquid activator is performed after the hydrogen-enhanced drug delivery system is applied to the target area of the subject's skin.
19. The method of claim 10 , wherein the subject has a disease, disorder, or condition of the integumentary system, and the method causes a treatment and/or mitigation of the disease, disorder, or condition of the integumentary system.
20. The method of claim 10 , wherein the therapeutic agent comprises herbs, herbal-derived compounds, oils, essential oils, Aloe vera, Hippophae rhamnoides , sea buckthorn, Angelica sinensis, Catharanthus roseus, Vinca rosea, Calendula officinalis , marigold, Sesamum indicum, Morinda citrifolia, noni, Camellia sinensis, Rosmarinus officinalis L ., rosemary, primrose oil, tea tree oil, propolis, honey, or honey-containing agents.