Compositions comprising oxo-derivatives of fatty acids and methods of making and using same
The present disclosure provides 15-oxo-EPA and 15-oxo-DGLA, compositions comprising 15-oxo-EPA and/or 15-oxo-DGLA, and methods of treating and/or preventing fibrosis, skin disorders, inflammation, kidney disease or renal dysfunction in a subject in need thereof by administering 15-oxo-EPA and/or 15-oxo-DGLA.
1. A method of treating inflammation in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising:
(a) (5Z, 8Z, 11Z, 13E, 17Z)-15-oxoicosa-5,8,11,13,17-pentaenoic acid (“15-oxo-EPA”) or (8Z, 11Z, 13E)-15-oxoicosa-8,11,13-trienoic acid (“15-oxo-DGLA”); and
(b) a pharmaceutically acceptable excipient.
2. A method of claim 1 , wherein the composition is orally administered.
3. The method of claim 1 , wherein the 15-oxo-EPA or the 15-oxo-DGLA is the only active ingredient in the composition.
4. The method of claim 1 , wherein the pharmaceutical composition comprises (5Z, 8Z, 11Z, 13E, 17Z)-15-oxoicosa-5,8,11,13,17-pentaenoic acid (“15-oxo-EPA”).
5. The method of claim 1 , wherein the pharmaceutical composition comprises (8Z, HZ, 13E)-15-oxoicosa-8,11,13-trienoic acid (“15-oxo-DGLA”).