Conversion of 1,2,5,6-hexanetetrol (HTO) to tetrahydrofuran dicarboxylic acid (THFDCA)
Disclosed herein are methods for synthesizing useful intermediates and/or products from 1,2,5,6-hexanetetrol (HTO), which itself can be derived from a sugar. In an aspect, a process is provided for production of THFDCA from 1,2,5,6-hexanetetrol (HTO). The process comprises the steps of (a) ring closing to form a ring compound and (b) oxidizing using a catalyst comprising platinum and bismuth to form an acid mixture. Step (a) may be performed before or after step (b).
1. A process comprising:
(a) oxidizing 1,2,5,6-hexanetetrol (HTO) while the HTO is in contact with a catalyst comprising Pt and Bi such that an acid mixture comprising 2,5-dihydroxyadipic acid and 2-hydroxyglutaric acid is formed, wherein more 2,5-dihydroxyadipic acid is formed than 2-hydroxyglutaric acid; and
(b) contacting 2,5-dihydroxyadipic acid formed in step (a) with an acid other than 2,5-dihydroxyadipic acid for a time sufficient to form the ring compound, wherein the formed ring compound is tetrahydrofuran dicarboxylic acid (THFDCA).