Instant early stage disease detection by decoding organic compound signatures
View Patent ↗The present invention provides a process and method for the early detection and diagnosis of disease by reading and decoding volatile organic compounds (VOCs) for signatures associated with a specific disease. From its outset, each disease begins producing its own unique set of volatile organic compounds. For many diseases, this early-stage detection may be many months or years before noticeable symptoms. The VOC emissions when analyzed, result in a “signature” that identifies and distinguishes the developing, or at later stages, the developed disease. The device assays non-invasively obtained biosamples in real-time to output a VOC based signature that, when correlated with data in a disease signature library, identifies one or more diseases associated with the sample.
1. An analytical device comprising a detector unit capable of interfacing with an analytical unit,
said detector unit comprising a plurality of detection surfaces capable of interacting with an ambient vapor phase;
said detector unit comprising an orifice for introducing a sample to be assayed;
said detection surface comprising a nano-sensor element (NSE) layer between an input and an output;
said input in contact with a base power source providing a variable feeder voltage;
said output in communication with at least one data collector;
said NSE layer associated with a selection component with selection specificity for one or more compounds of interest;
said selection component when in contact with or in close proximity to a target compound possibly present in said vapor phase selectively altering signal to said output; and
a component for collecting said signal from said output.
2. The device of claim 1 wherein said feeder voltage varies between a minimum and a maximum, said minimum >−2 v and said maximum <+4 v.
3. An analytical device comprising a detector unit capable of interfacing with an analytical unit,
said detector unit comprising a plurality of detection surfaces capable of interacting with an ambient vapor phase;
said detector unit comprising an orifice for introducing a sample to be assayed;
said detection surface comprising a nano-sensor element (NSE) layer between an input and an output;
said input in contact with a base power source, aid input comprising an input electrode said input electrode having a base or feeder voltage between −10 v and +10 v;
said output in communication with at least one data collector;
said NSE layer associated with a selection component with selection specificity for one or more compounds of interest;
said selection component when in contact with or in close proximity to a target compound possibly present in said vapor phase selectively altering signal to said output; and
a component for collecting said signal from said output.
4. An analytical device comprising a detector unit capable of interfacing with an analytical unit,
said detector unit comprising a plurality of detection surfaces capable of interacting with an ambient vapor phase;
said detector unit comprising an orifice for introducing a sample to be assayed;
said detection surface comprising a nano-sensor element (NSE) layer between an input and an output;
said input in contact with a base power source;
said output in communication with at least one data collector;
said NSE layer associated with a selection component with selection specificity for one or more compounds of interest;
said selection component when in contact with or in close proximity to a target compound possibly present in said vapor phase selectively altering signal to said output; and
a component for collecting said signal from said output;
said analytical device further comprising at least one physical electromagnetic shielding component that shields the sensing chamber from undesired physical effects;
wherein said electromagnetic shielding comprises conductive material.
5. The device of claim 4 wherein said conductive material is selected from the group consisting of: copper, nickel, mu-metal, conductive plastics, conductive paints and conductive inks.
6. An analytical device comprising a detector unit capable of interfacing with an analytical unit,
said detector unit comprising a plurality of detection surfaces capable of interacting with an ambient vapor phase;
said plurality of detection surfaces comprising a plurality of nanosensing elements distributed amongst a plurality of groups, at least one of said groups under control of a switch, said switch determining availability of said groups to alter signal to said output and wherein at least two of said groups are controllable to different base voltages;
said detector unit comprising an orifice for introducing a sample to be assayed;
said detection surface comprising a nano-sensor element a SE) layer between an input and an output;
said input in contact with a base power source;
said output in communication with at least one data collector;
said NSE layer associated with a selection component with selection specificity for one or more compounds of interest;
said selection component when in contact with or in close proximity to a target compound possibly present in said vapor phase selectively altering signal to said output; and
a component for collecting said signal from said output.