Antiviral compounds
The present disclosure provides a compound of Formula I: which is useful in treating a variety of diseases, such as diseases caused by respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, HCV and/or HBV infections.
1. A compound of Formula I:
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical formulation comprising a therapeutically effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient.
3. A method of treating a Pneumoviridae virus infection in a human in need thereof, the method comprising administering to the human a therapeutically effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the Pneumoviridae virus infection is a respiratory syncytial virus infection.
4. A method of treating a Picornaviridae virus infection in a human in need thereof, the method comprising administering to the human a therapeutically effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the Picornaviridae virus infection is human rhinovirus infection.
5. A method for the treatment or prophylaxis of an exacerbation of a respiratory condition by a viral infection in a human in need thereof, the method comprising administering to the human a therapeutically effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the respiratory condition is chronic obstructive pulmonary disease, and wherein the infection is caused by a respiratory syncytial virus or rhinovirus.
6. A method for the treatment or prophylaxis of an exacerbation of a respiratory condition by a viral infection in a human in need thereof, the method comprising administering to the human a therapeutically effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the respiratory condition is asthma, and wherein the infection is caused by respiratory syncytial virus or rhinovirus.
7. A compound having the structure:
8. A pharmaceutical composition comprising a compound having the structure:
and a pharmaceutically acceptable excipient.