Dihydroquinolinones for medical treatment

1. A method for the treatment of cancer comprising administering an effective amount of a compound of formula:

or a pharmaceutically acceptable salt thereof to a patient in need thereof;

wherein

X 1 is CH or N;

X 2 is CH or N;

X 3 is CH or N,

wherein one of X 1 , X 2 or X 3 is N and the other two are CH;

R 1 is selected from the group consisting of

i) —C(═O)—R 6 ;

ii) heterocyclyl;

iii) heterocyclyl, substituted by 1 or 2 substituents individually selected from R 10 ;

iv) aryl; and

v) aryl, substituted by 1 or 2 substituents individually selected from R 9 ;

R 2 is H, or R 1 and R 2 together with the nitrogen they are attached to form a heteroaryl, which is optionally substituted by 1 or 2 substituents individually selected from R 3 ;

R 3 is selected from the group consisting of:

i) —(CH 2 ) 0-1 -aryl substituted by 1 or 2 substituents selected from R 4 ;

ii) —(CH 2 ) 0-2 —N(R 3c )C(═O)—C 3-7 cycloalkyl;

iii) amino-C 1-6 alkyl;

iv) —C(═O)N(R 3a ,R 3b );

v) C(═O)O—C 1-6 alkyl;

vi) C 1-6 alkyl; and

vii) —C 3-7 cycloalkyl;

R 3a is selected from the group consisting of hydrogen and C 1-6 alkyl;

R 3b is selected from the group consisting of hydrogen and C 1-6 alkyl; or R 3a and R 3b form together with the nitrogen to which they are attached form a heterocycloalkyl;

R 3c is hydrogen;

R 4 is selected from the group consisting of amino, —C(═O)N(R 3a ,R 3b ), C 1-6 alkoxy, C 1-6 alkyl, halo-C 1-6 alkyl, and hydroxy-C 1-6 alkyl;

R 6 is selected from the group consisting of

i) unsubstituted aryl;

ii) unsubstituted heteroaryl; and

iii) heteroaryl substituted by 1 or 2 substituents selected from R 7 ;

R 7 is selected from the group consisting of

i) unsubstituted heteroaryl; and

ii) heteroaryl substituted by 1 or 2 substituents selected from R 8 ;

R 8 is C 1-6 alkyl;

Y is CH 2 or NH;

R 9 is selected from the group consisting of

i) C 1-6 alkyl; and

ii) —C(═O)O—C 1-6 alkyl;

R 10 is selected from the group consisting of

i) C 1-6 alkyl; and

ii) —C(═O)O—C 1-6 alkyl.

2. The method of claim 1 , wherein X 1 is N.

3. The method of claim 1 , wherein X 2 is N.

4. The method of claim 1 , wherein X 3 is N.

5. The method of claim 1 , wherein R 3 is aryl substituted by 1 or 2 substituents selected from R 4 , wherein R 4 is selected from the group consisting of —C(═O)N(R 3a ,R 3b ), C 1-6 alkyl, and C 1-6 alkoxy.

6. The method of claim 1 , wherein R 3 is-C(═O)N(R 3a ,R 3b ).

7. The method of claim 6 , wherein R 3a is hydrogen and R 3b is C 1-6 alkyl.

8. The method of claim 7 , wherein R 3b is methyl.

9. The method of claim 1 , wherein R 1 is-C(═O)—R 6 .

10. The method of claim 1 , wherein R 1 is heterocyclyl.

11. The method of claim 1 , wherein R 1 is heterocyclyl, substituted by 1 or 2 substituents individually selected from R 10 .

12. The method of claim 1 , wherein R 1 is aryl.

13. The method of claim 1 , wherein R 1 is aryl, substituted by 1 or 2 substituents individually selected from R 9 .