Anti-tumor compound and preparation method and use thereof

1. An antibody-drug conjugate having the following structure:

or a pharmaceutically acceptable salt thereof, wherein n is the connection number, and n is selected from the group consisting of 1 to 10.

2. The antibody-drug conjugate or pharmaceutically acceptable salt thereof according to claim 1 , wherein n is 6 to 8.

3. The antibody-drug conjugate or pharmaceutically acceptable salt thereof according to claim 2 , wherein n is 7.

4. The antibody-drug conjugate or pharmaceutically acceptable salt thereof according to claim 2 , wherein n is 8.

5. The antibody-drug conjugate or pharmaceutically acceptable salt thereof according to claim 1 , wherein trastuzumab comprises a light chain comprising an amino acid sequence set forth in SEQ ID NO: 33, and a heavy chain comprising an amino acid sequence set forth in SEQ ID NO: 37.

6. A pharmaceutical composition comprising an antibody-drug conjugate or pharmaceutically acceptable salt thereof of claim 1 , or a mixture thereof, and a pharmaceutically acceptable carrier or diluent.

7. A method of treating cancer in a subject in need thereof, comprising administering to said subject the antibody-drug conjugate or pharmaceutically acceptable salt thereof of claim 1 .

8. The method of claim 7 , wherein the cancer is selected from the group consisting of lung cancer, kidney cancer, urinary tract carcinoma, colorectal cancer, prostatic cancer, glioblastoma multiforme, ovarian cancer, pancreatic cancer, breast cancer, melanoma, liver cancer, bladder cancer, stomach cancer and esophageal cancer.

9. The method of claim 8 , wherein the cancer is selected from the group consisting of breast cancer and stomach cancer.

10. The antibody-drug conjugate or pharmaceutically acceptable salt thereof according to claim 2 , wherein n is 6.