Compound having novel structure, complex comprising same, anti-cancer pharmaceutical composition, and anti-cancer drug
Disclosed is a compound, a complex comprising same, an anti-cancer pharmaceutical composition, and an anti-cancer drug. The compound can have the structure represented by chemical formula 1.
1. A compound having a structure represented by the following Chemical Formula 1:
wherein in the Chemical Formula 1, X 1 represents NH, O or S,
wherein L represents
wherein A represents one of the following Chemical Formulas A-1 to A-3:
wherein in the Chemical Formula A-2, each of R 1 to R 8 independently represents H, OCH 3 or F,
wherein in the Chemical Formula A-3, X 2 represents NH, O or S.
2. The compound of claim 1 , wherein the compound has a structure represented by one of following Chemical Formulas 1-1 to 1-3:
3. A pharmaceutical composition containing the compound of claim 1 at an effective amount and further containing a pharmaceutically acceptable carrier, wherein the composition has anticancer activity on cancer cells.
4. The pharmaceutical composition of claim 3 , wherein the composition targets cancer cells of at least one selected from a group consisting of colorectal cancer, breast cancer, liver cancer, brain glioma, lung cancer, prostate cancer, kidney cancer and cervical cancer, and has anticancer activity on the cancer cells.
5. The pharmaceutical composition of claim 3 , wherein when the compound has a structure of Chemical Formula 1-1
the composition has anticancer activity against colorectal cancer, breast cancer, liver cancer, brain glioma, lung cancer, prostate cancer or kidney cancer.
6. The pharmaceutical composition of claim 3 , wherein when the compound has a structure of Chemical Formula 1-2
the composition has anticancer activity against colorectal cancer, breast cancer, liver cancer, brain glioma, lung cancer, prostate cancer or kidney cancer.
7. The pharmaceutical composition of claim 3 , wherein when the compound has a structure of Chemical Formula 1-3
the composition has anticancer activity against colorectal cancer, breast cancer, brain glioma, prostate cancer or kidney cancer.
8. A complex containing a compound having a structure represented by a following Chemical Formula 1 as a ligand, and a metal atom coordinated to the ligand:
wherein in the Chemical Formula 1, X 1 represents NH, O or S,
wherein L represents
wherein A represents one of following Chemical Formulas A-1 to A-3:
wherein in the Chemical Formula A-2, each of R 1 to R 8 independently represents H, OCH 3 or F,
wherein in the Chemical Formula A-3, X 2 represents NH, O or S.
9. The complex of claim 8 , wherein the metal atom is platinum (Pt).
10. The complex of claim 8 , wherein the complex has a structure represented by one of following Chemical Formulas 3-1 to 3-3:
11. A pharmaceutical composition containing the complex of claim 8 at an effective amount and further containing a pharmaceutically acceptable carrier, wherein the composition has anticancer activity on cancer cells.
12. The pharmaceutical composition of claim 11 , wherein the composition targets cancer cells of at least one selected from a group consisting of colorectal cancer, breast cancer, liver cancer, brain glioma, lung cancer, prostate cancer, kidney cancer and cervical cancer, and has anticancer activity on the cancer cells.
13. The pharmaceutical composition of claim 11 , wherein when the complex has a structure represented by Chemical Formula 3-1
the composition has anticancer activity against colorectal cancer, breast cancer, liver cancer, brain glioma, lung cancer, prostate cancer or kidney cancer.
14. The pharmaceutical composition of claim 11 , wherein when the complex has a structure represented by Chemical Formula 3-2
the composition has anticancer activity against colorectal cancer.
15. The pharmaceutical composition of claim 11 , wherein when the complex has a structure represented by Chemical Formula 3-3
the composition has anticancer activity against liver cancer.
16. An anticancer drug containing, as an active ingredient, the compound of claim 1 .
17. An anticancer drug containing, as an active ingredient, the complex of claim 8 .
18. An anticancer drug containing, as an active ingredient, the pharmaceutical composition of claim 3 .
19. An anticancer drug containing, as an active ingredient, the pharmaceutical composition of claim 11 .