Vascular anastomotic member comprising shape-memory polymer
The present invention relates to an artificial blood vessel comprising a shape-memory polymer, and a vascular anastomotic member formed of a shape-memory polymer. An artificial blood vessel according to an embodiment of the present invention comprises a shape-memory polymer including photo-crosslinkable functional groups, the artificial blood vessel thus provided having a fusion point suitable for in vivo transplantation. Also, provided is a vascular anastomotic member which comprises a shape-memory polymer including photo-crosslinkable functional groups, and thus has a fusion point suitable for in vivo transplantation.
1. A vascular anastomotic member comprising a shape-memory polymer represented by Formula 1 below:
wherein, in Formula 1, R 1 , R 2 and R 3 are each independently hydrogen (H) or a C1 to C6 alkyl group,
m and n are each independently an integer of 1 to 20,
A, B 1 and B 2 are each independently oxygen (O) or sulfur(S),
x and y represent mol % of a repeat unit,
x+y is 100, and
x is 80 to 95.
2. The vascular anastomotic member of claim 1 , wherein, in Formula 1, R 1 , R 2 and R 3 are each independently hydrogen (H) or a methyl group,
m and n are each independently an integer of 3 to 12,
A, B 1 and B 2 are each independently oxygen (O) or sulfur(S),
x and y represent mol % of a repeat unit,
x+y is 100, and x is 88 to 94.
3. The vascular anastomotic member of claim 1 , wherein the shape-memory polymer has a melting temperature of 30 to 48° C. on average.
4. The vascular anastomotic member of claim 1 , wherein the shape-memory polymer has an average melting temperature of 28 to 42° C. after crosslinking.
5. The vascular anastomotic member of claim 1 , comprising a shape-memory polymer represented by Formula 2:
wherein, in Formula 2, m and n are each independently an integer of 1 to 20,
x and y represent mol % of a repeat unit,
x+y is 100, and
x is 80 to 95.
6. The vascular anastomotic member of claim 1 , wherein the vascular anastomotic member has a tubular shape inserted into ends of a first blood vessel and a second blood vessel.
7. The vascular anastomotic member of claim 6 , wherein the vascular anastomotic member is changed according to the inner diameters of the first blood vessel and the second blood vessel at 28 to 42° C. or more on average.
8. The vascular anastomotic member of claim 6 , wherein the vascular anastomotic member has a sectional thickness of 50 to 200 μm.
9. The vascular anastomotic member of claim 6 , wherein the vascular anastomotic member has an inner diameter of 0.2 to 5 mm, and the inner diameter of the vascular anastomotic member gradually increases from a first direction to a second direction.
10. The vascular anastomotic member of claim 6 , comprising:
a plurality of fixing protrusions fixed to a blood vessel on an outer circumference surface of the vascular anastomotic member.
11. The vascular anastomotic member of claim 1 , wherein the vascular anastomotic member has a sheet shape surrounding a damaged site of a blood vessel, and whose shape is changed to surround an outer diameter of the blood vessel at 28 to 42° C. or more on average.
12. The vascular anastomotic member of claim 11 , wherein a perforation is formed in one area of the vascular anastomotic member, and a branch tube is integrally connected to an area corresponding to the perforation.
13. The vascular anastomotic member of claim 12 , wherein an inner diameters of the perforation and the branch tube correspond to each other, and the branch tube is configured to communicate with the damaged site of the blood vessel.
14. The vascular anastomotic member of claim 12 , wherein the branch tube has a guide protrusion on an inner circumference surface, and the guide protrusion is expanded in a longitudinal direction along the axis of the branch tube.
15. The vascular anastomotic member of claim 12 , wherein the branch tube comprises one or more types of biocompatible polymers selected from the group consisting of polyethylene glycol, polyglycolide, poly-L-lactide, poly-D,L-lactide, poly(lactide-co-glycolide) and hyaluronic acid.
16. The vascular anastomotic member of claim 11 , comprising:
a plurality of protrusions which are located on a back side of the vascular anastomotic member and configured to be fixed to the blood vessel.
17. The vascular anastomotic member of claim 1 , wherein the vascular anastomotic member comprises an antithrombotic material.