Rifaximin
Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
1. A pharmaceutical composition in tablet form essentially free of crystalline rifaximin, the tablet comprising amorphous rifaximin, colloidal silicon dioxide, and microcrystalline cellulose.
2. The pharmaceutical composition of claim 1 , comprising a suitable film coating.
3. A method of treating a bowel related disorder in a patient in need thereof, the method comprising administering a therapeutically effective amount of the pharmaceutical composition of claim 1 to the patient.
4. The method of claim 3 , wherein the bowel related disorder is selected from the group consisting of irritable bowel syndrome, traveler's diarrhea, Crohn's disease, chronic pancreatitis, pancreatic insufficiency, and colitis.