Bioactive agents included in functionalized starch having a single helix V-structure
The present document describes a powder composition comprising a functionalized starch having a single helix V-structure and having a degree of substitution of at least 0.25, and a bioactive agent, forming an inclusion complex with said functionalized starch, where the bioactive agent is within the helix V-structure of the functionalized starch having a single helix V-structure. Also described are the functionalized starch having a single helix V-structure and having a degree of substitution of at least 0.25, methods of making the same and methods of using the same to manufacture the powder composition.
1. A powder composition comprising:
a carboxymethylated starch powder prepared by the following process:
(a) placing a native starch and sodium monochloroacetate (SMCA) in an alkaline solvent-water medium having a solvent:water ratio of from about 70% to about 95% (vol/vol) solvent in water and at least 3 M sodium hydroxide (NaOH), and stirring for at least 10 hours at a temperature of from about 22° C. to about 28° C. to generate a carboxymethylated starch; and
(b) washing and drying the carboxymethylated starch from step (a) to generate the carboxymethylated starch powder,
and
a poorly water-soluble or water insoluble bioactive agent, forming a water-soluble or water dispersible inclusion complex with said carboxymethylated starch powder,
wherein said carboxymethylated starch powder and said bioactive agent are present in a ratio of about 4:1 to about 1:1 w/w.
2. The powder composition of claim 1 , wherein said carboxymethylated starch has a degree of substitution (DS) from about 0.25 to about 1.5.
3. The powder composition of claim 1 , wherein said carboxymethylated starch has a DS from about 0.4 to about 0.7.
4. The powder composition of claim 1 , wherein said native starch is a corn starch, a potato starch, a pea starch, a rice starch, a bean starch, a wheat starch, or combinations thereof.
5. The powder composition of claim 4 , wherein said native starch is a potato starch.
6. The powder composition of claim 1 , wherein said solvent-water medium is an alcohol-water medium.
7. The powder composition of claim 6 , wherein said alcohol-water medium is an ethanol-water medium or isopropanol-water medium.
8. The powder composition of claim 1 , wherein said bioactive agent is a simple fatty acid, a lipid compound, a complex lipid, an antibiotic, a protein, a peptide, a pharmaceutically active ingredient or combinations thereof.
9. The powder composition of claim 8 , wherein said simple fatty acid is alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, or combinations thereof.
10. The powder composition of claim 8 , wherein said complex lipid is a glyceride, a carotenoid, a terpenoid, an isoprenoid, a with anolide, a cholesterol, a phytosterol, a liposoluble vitamin, a stilbenoid, or combinations thereof.
11. The powder composition of claim 10 , wherein said glyceride is omega-3 monoglyceride, omega-3 diglyceride, omega-3 triglycerides, or combinations thereof.
12. A pharmaceutical composition comprising:
the powder composition of claim 1 , and
a pharmaceutically acceptable carrier.
13. The pharmaceutical composition of claim 12 , wherein said bioactive agent is artemisinin or its derivatives.
14. A method of treating malaria comprising administering to a subject in need thereof the powder composition of claim 1 , wherein said bioactive agent is artemisinin.