Granted Patent B2

US 12,133,905 · App. 17/503,553 · Granted Nov 5, 2024

Inventors: Jayanth Rajaiah (Loveland, OH); Paul Albert Sagel (Mainville, OH); Franco Silva Medeiros (Loveland, OH)

Assignee: The Procter & Gamble Company

A61K8/064A61C19/066A61K8/0216A61K8/062A61K8/22A61K8/31A61K8/345A61K8/8111A61K8/86A61K8/92A61N5/0603A61N5/062A61Q11/00A61Q11/02A61K2800/42A61K2800/81A61K2800/87A61K2800/884A61K2800/92A61N2005/0606A61N2005/0663

Abstract

Claims (23)

1. A multi-phase oral composition comprising:

a) from about 0.002% to about 50%, by weight of the multi-phase oral composition, of an aqueous phase having a bleaching agent; and

b) a semi-solid hydrophobic phase, wherein the semi-solid hydrophobic phase comprises petrolatum or microcrystalline wax, and wherein the multi-phase oral composition comprises at least about 50%, by weight of the multi-phase oral composition, of the petrolatum or the microcrystalline wax;

wherein a ratio of the concentration in weight percent of bleaching agent present in the aqueous phase to a concentration in weight percent of bleaching agent present in the multi-phase oral composition is at least about 5;

wherein a concentration of the bleaching agent is up to about 20%, by weight of the multi-phase oral composition; and

wherein the multi-phase oral composition is a water-in-oil emulsion having droplets of the aqueous phase dispersed within the semi-solid hydrophobic phase.

2. The multi-phase oral composition according to claim 1 , wherein the ratio of the concentration in weight percent of bleaching agent present in the aqueous phase to the concentration in weight percent of bleaching agent present in the multi-phase oral composition is at least about 10.

3. The multi-phase oral composition according to claim 2 , wherein the ratio of the concentration in weight percent of bleaching agent present in the aqueous phase to the concentration in weight percent of bleaching agent present in the multi-phase oral composition is at least about 15.

4. The multi-phase oral composition according to claim 1 , wherein an amount of the bleaching agent ranges from about 0.01% to about 10% by weight of the multi-phase oral composition.

5. The multi-phase oral composition according to claim 1 , wherein a two-dimensional density of droplets with a cross-sectional area larger than about 10000 square microns is no more than about 20 per square centimeter.

6. The multi-phase oral composition according to claim 5 , wherein the two-dimensional density of droplets with a cross-sectional area larger than about 10000 square microns is no more than about 10 per square centimeter.

7. The multi-phase oral composition according to claim 1 , wherein a standard deviation of the peroxide intensity of the multi-phase oral composition smeared onto peroxide test strips is no more than about 50.

8. The multi-phase oral composition according to claim 7 , wherein the standard deviation of the peroxide intensity of the multi-phase oral composition smeared onto peroxide test strips is no more than about 25.

9. The multi-phase oral composition according to claim 1 , wherein a mean peroxide intensity of the multi-phase oral composition smeared onto peroxide test strips is from about 1 to about 100.

10. The multi-phase oral composition according to claim 1 , wherein the mean residual peroxide intensity of the multi-phase oral composition smeared on teeth is from about 20 to about 200.

11. The multi-phase oral composition according to claim 1 , wherein the bleaching agent comprises hydrogen peroxide.

12. The multi-phase oral composition according to claim 1 , wherein a bleaching efficacy of the multi-phase oral composition calculated as −Δb* is at least about 1.5.

13. The multi-phase oral composition according to claim 1 , wherein a ratio of the bleaching efficacy of the multi-phase oral composition calculated as −Δb* to a weight percentage of bleaching agent present in the multi-phase oral composition is at least about 1.5.

14. The multi-phase oral composition according to claim 1 , further comprising a delivery carrier.

15. The multi-phase oral composition according to claim 14 , wherein the delivery carrier is a strip.

16. The multi-phase oral composition according to claim 15 , wherein the strip is a deformable strip.

17. The multi-phase oral composition according to claim 1 , further comprising from 0% to about 0.1%, by weight of the multi-phase oral composition, of emulsifier.

18. The multi-phase oral composition according to claim 1 , wherein the multi-phase oral composition is free of mineral oil.

Continuity (9)