Composition and application thereof as antitumor drug
A composition is prepared from a platinum-based antitumor compound and a novel compound, and the novel compound is sodium(S)-2-(dithiocarboxylate ((2S, 3R, 4R, 5R)-2,3,4,5,6-pentahydroxyhexyl)amino)-4-(methylthio)butyrate. The novel compound in the composition could effectively chelate the platinum-based antitumor compound and reduce the various adverse effects exhibited by the platinum-based compound. The dosage of the platinum-based antitumor compound can thus be increased, and the antitumor effect can be optimized. The novel compound itself is low-toxic and it has low chelating activities with essential metals in the human body; it would not impose significant adverse effects on the human body at given doses. The composition and its application as an antitumor drug overcome some technical drawbacks of platinum-based antitumor drugs, namely severe adverse effects and the development of drug resistance during administration.
1. A method of treating solid tumors in a subject suffering from cancer, including:
administering a drug to the subject, wherein the drug comprises, in parts by mole, 1-5 parts of a platinum-based antitumor compound and 1-50 parts of sodium (S)-2-(dithiocarboxylate ((2S,3R,4R),5R)-2,3,4,5,6-pentahydroxyhexyl)amino)-4-(methylthio)butyrate (GMDTC).
2. The method according to claim 1 , wherein the platinum-based antitumor compound is one or more selected from the group consisting of cisplatin, oxaliplatin, and carboplatin.
3. The method according to claim 2 , wherein the platinum-based antitumor compound is cisplatin.
4. The method according to claim 1 , wherein the drug comprises, in parts by mole, 1-3 parts of the platinum-based antitumor compound and 1-20 parts of GMDTC.
5. The method according to claim 4 , wherein the drug comprises, in parts by mole, 1 part of the platinum-based antitumor compound and 20 parts of GMDTC.
6. The method according to claim 1 , wherein GMDTC is administered 2 hours after administration of cisplatin.
7. The method according to claim 1 , wherein the cancer is breast cancer.