IP Library Granted Patent US 12,142,158
Granted Patent B2
US 12,142,158 · App. 17/297,956 · Granted Nov 12, 2024

Stomach simulating device

Inventors: Rosemary Kanasty (Cambridge, MA); Tyler Grant (Arlington, MA); John James Healy (Rexford, NY); Benjamin August Rothenberg Peterson (Portland, ME); Todd William Roberts (St. Inigoes, MD); Nathan Andrew Herrmann (Middlebury, VT); Erik Robert Waldemar Ryde (Boston, MA); David C. Dufour (Watertown, MA); Carmi Mandelkern (Watertown, MA); Jacob Freake (Watertown, MA); Kristofer Kurtin (Watertown, MA); Douglas Sabin (Watertown, MA)
Assignee: LYNDRA THERAPEUTICS, INC.
G09B23/32F04B13/00F04B43/12
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Quick Facts
Patent No.
US 12,142,158
App. No.
17/297,956
Granted
Nov 12, 2024
Kind
B2
Abstract

Provided are stomach simulating devices and methods for simulating a stomach. Stomach simulating devices can comprise a bag-shaped conduit, a mechanical constrictor, and a valve. The conduit can have a body portion, a first diameter at an inlet portion, and a second diameter at an outlet portion, wherein the first diameter at the inlet portion is greater than the second diameter at the outlet portion, the body portion is located between the inlet portion and the outlet portion, and at least a portion of the conduit is curved in a direction from the inlet portion the outlet portion. The mechanical constrictor can he configured to constrict at least a portion of the body portion of the conduit. The valve can be configured to at least partially close a portion of the conduit closer to the outlet portion than the inlet portion of the conduit.

Claims (24)

1. A stomach simulating device comprising:

a conduit having a body portion, a first inner diameter, and a second inner diameter, and an outer diameter, wherein the first inner diameter is larger than the second inner diameter, and wherein the conduit comprises a plurality of circumferential channels along an exterior surface; and

a plurality of cable constrictors, wherein each cable constrictor of the plurality of cable constrictors is configured to constrict a portion of the body portion of the conduit.

2. The stomach simulating device of claim 1 , wherein an exterior surface of the conduit is cylindrical.

3. The stomach simulating device of claim 1 , wherein the conduit comprises silicone.

4. The stomach simulating device of claim 1 , wherein an opening of the conduit comprises a diameter of 30-60 mm.

5. The stomach simulating device of claim 1 , wherein the conduit comprises a minimum diameter in an unconstricted conduit of 15-30 mm.

6. The stomach simulating device of claim 1 , wherein the conduit comprises a wall thickness of 1-15 mm.

7. The stomach simulating device of claim 1 , wherein a first cable constrictor of the plurality of cable constrictors wraps around an exterior circumference of the conduit.

8. The stomach simulating device of claim 7 , wherein the first cable constrictor is positioned within a first circumferential channel.

9. The stomach simulating device of claim 1 , wherein the plurality of cable constrictors is bonded to the stomach bag conduit with silicone.

10. The stomach simulating device of claim 1 , wherein the plurality of cable constrictors comprises 10-20 cable constrictors.

11. The stomach simulating device of claim 1 , wherein the conduit comprises a first silicone of durometer 00-30 and a second silicone of durometer 18A as measured using ASTM D2240.

12. The stomach simulating device of claim 1 , wherein each cable constrictor of the plurality of cable constrictors comprises a looped steel wire wrapped with a polyester rope, and each cable constrictor is configured to concentrically constrict a portion of the body portion of the conduit when a circumference of the steel wire decreases.

13. The stomach simulating device of claim 1 , wherein each cable constrictor is configured to concentrically constrict the conduit when one or more ends of a looped steel wire are pulled to decrease a circumference of the looped steel wire.

14. The stomach simulating device of claim 1 , wherein constriction of each cable constrictor of the plurality of cable constrictors is coordinated.

15. The stomach simulating device of claim 1 , wherein the conduit is configured to rotate from a horizontal position to a vertical position, and from the vertical position to the horizontal position.

16. The stomach simulating device of claim 1 , wherein a lubricant is applied to an interior surface of the conduit.

17. A stomach simulating device comprising:

a conduit having a body portion, a first inner diameter, and a second inner diameter, and an outer diameter, wherein the first inner diameter is larger than the second inner diameter; and

a plurality of cable constrictors, wherein each cable constrictor of the plurality of cable constrictors is configured to constrict a portion of the body portion of the conduit, wherein a first cable constrictor of the plurality of cable constrictors wraps around an exterior surface of the conduit, wherein the first cable constrictor is positioned within a first circumferential channel.

18. The stomach simulating device of claim 17 , wherein the conduit comprises a plurality of circumferential channels along an exterior surface.

19. The stomach simulating device of claim 17 , wherein each cable constrictor of the plurality of cable constrictors comprises a looped steel wire wrapped with a polyester rope, and each cable constrictor is configured to concentrically constrict a portion of the body portion of the conduit when a circumference of the looped steel wire decreases.

20. The stomach simulating device of claim 17 , wherein constriction of each cable constrictor of the plurality of cable constrictors is coordinated.

Assignments (7)
CHANGE OF NAME Recorded Nov 19, 2025
From: ISP ACQUISITION COMPANY, INC.
To: NORTIVA BIO, INC.
Reel/Frame 073607/0955 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 18, 2025
From: LYNDRA THERAPEUTICS, INC.
To: ISP ACQUISITION COMPANY, INC.
Reel/Frame 073610/0424 →
RELEASE OF SECURITY INTEREST Recorded Dec 28, 2023
From: ISP HOLDINGS LLC
To: LYNDRA THERAPEUTICS, INC.
Reel/Frame 065970/0490 →
CHANGE OF NAME Recorded Mar 24, 2023
From: LYNDRA, INC.
To: LYNDRA THERAPEUTICS, INC.
Reel/Frame 063164/0834 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 24, 2023
From: DUFOUR, DAVID C.
To: LYNDRA, INC.
Reel/Frame 063092/0929 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 24, 2023
From: KANASTY, ROSEMARY; GRANT, TYLER; HEALY, JOHN JAMES; PETERSON, BENJAMIN AUGUST ROTHENBERG; ROBERTS, TODD WILLIAM; HERRMANN, NATHAN ANDREW; RYDE, ERIK ROBERT WALDEMAR; MANDELKERN, CARMI; FREAKE, JACOB; KURTIN, KRISTOFER; SABIN, DOUGLAS
To: LYNDRA THERAPEUTICS, INC.
Reel/Frame 063163/0872 →
SECURITY INTEREST Recorded Jul 13, 2022
From: LYNDRA THERAPEUTICS, INC.
To: ISP HOLDINGS LLC
Reel/Frame 060499/0525 →
Continuity (2)
Provisional Application 62774802 · Dec 3, 2018
Related Publication 20220093006A1 · Mar 24, 2022
Cited By (3)
US 12,447,130 US 12,582,608 US 12,734,128