Prosthetic heart valves

1. A prosthetic heart valve comprising:

a main body and an anterior flap, the main body comprising an inflow end portion and an outflow end portion; and

an occluder extending between the inflow end and outflow end portions and defining a longitudinal axis, the occluder comprising valve leaflets attached to the main body in an arrangement that: (i) allows blood flow through the occluder in a direction from the inflow end portion toward the outflow end portion and (ii) prevents blood flow through the occluder in a direction from the outflow end portion toward the inflow end portion, the occluder having a circular cross-sectional shape and a radius,

wherein the anterior flap comprises a first portion, a mid-body portion, and a terminal end portion that extends from the mid-body portion,

wherein the first portion is attached to the outflow end portion of the main body and extends substantially perpendicularly from the outflow end portion of the main body to the mid-body portion,

wherein the mid-body portion is bent at an angle that directs the terminal end portion of the anterior flap partially toward the inflow end portion, and

wherein a tip of the terminal end portion of the anterior flap is spaced apart from the main body by a distance greater than the radius.

2. The prosthetic heart valve of claim 1 , wherein the angle is between 20° and 60°.

3. The prosthetic heart valve of claim 1 , wherein the anterior flap is a first anterior flap, and wherein the prosthetic heart valve further comprises a second anterior flap extending away from the outflow end portion of the main body.

4. The prosthetic heart valve of claim 3 , wherein portions of the first anterior flap and the second anterior flap are configured to overlap each other when the prosthetic heart valve is deployed.

5. The prosthetic heart valve of claim 4 , wherein an open space is defined between the first anterior flap and the second anterior flap when the prosthetic heart valve is deployed.

6. The prosthetic heart valve of claim 1 , further comprising a covering attached to the anterior flap, wherein the covering defines an opening through the terminal end portion of the anterior flap.

7. A method of deploying a prosthetic heart valve, the method comprising:

advancing, via a femoral vein and an inferior vena cava, the prosthetic heart valve toward a native tricuspid valve while the prosthetic heart valve is releasably coupled to a prosthetic heart valve deployment system and diametrically constrained in a low-profile delivery configuration within a first lumen of an outer sheath, wherein the prosthetic heart valve comprises:

a main body comprising an inflow end portion and an outflow end portion; and

one or more anterior flaps extending from the outflow end portion; and

expressing the prosthetic heart valve from the outer sheath, wherein the inflow end portion of the prosthetic heart valve is expressed only after an entirety of the outflow end portion has been expressed, and wherein the one or more anterior flaps extend into a right ventricular outflow tract (RVOT) as a result of the expressing of the prosthetic heart valve from the outer sheath.

8. The method of claim 7 , wherein the prosthetic heart valve deployment system further comprises:

a middle deflectable catheter slidably disposed in the first lumen and defining a second lumen, the middle deflectable catheter comprising a selectively deflectable distal end portion.

9. The method of claim 8 , wherein the prosthetic heart valve deployment system further comprises:

an inner control catheter slidably disposed in the second lumen and including one or more control wires that are releasably coupled with the prosthetic heart valve.

10. The method of claim 9 , wherein the inner control catheter includes a curved distal end portion that is curved by less than 20° when constrained in the first lumen.

11. The method of claim 10 , further comprising:

advancing the inner control catheter relative to the outer sheath to allow the curved distal end portion to become unconstrained and to elastically transition to a curved configuration in a posterior direction that is curved by at least 45° relative to the outer sheath.

12. The method of claim 10 , further comprising:

advancing the inner control catheter relative to the outer sheath to allow the curved distal end portion to become unconstrained and to elastically transition to a curved configuration that is curved by at least 45° relative to the outer sheath.

13. The method of claim 9 , further comprising:

deflecting the selectively deflectable distal end portion of the middle deflectable catheter so that the inner control catheter and the middle deflectable catheter in combination are curved by at least 90° relative to the outer sheath.

14. The method of claim 7 , wherein the one or more anterior flaps engage with a lateral wall of the RVOT to provide anchoring during diastole.

15. The method of claim 7 , wherein a portion of an opening defined by the native tricuspid valve is covered and fluidly sealed by the one or more anterior flaps.

16. The method of claim 7 , wherein the prosthetic heart valve deployment system and the prosthetic heart valve are advanced over a pre-placed guidewire.

17. The method of claim 7 , wherein the outflow end portion of the prosthetic heart valve comprises one or more posterior flaps that engage with a posterior shelf and/or with a wall of the right ventricle just inferior to an annulus of the native tricuspid valve.