Formulations of pyrimidine cyclohexyl glucocorticoid receptor modulators
The present invention provides formulations of (E)-6-(4-Phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione, and methods of making and using the same.
1. A composition comprising:
Compound I, (E)-6-(4-Phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione:
in an amount from 20.0 to 28.0% (w/w);
a poly[(methyl methacrylate)-co-(methacrylic acid)] in an amount from 20.0 to 28.0% (w/w);
sodium lauryl sulfate in an amount from 0.5 to 5.0% (w/w);
a sustaining polymer which is hydroxypropyl methylcellulose acetate succinate (HPMCAS), in an amount from 10.0 to 28.0% (w/w);
microcrystalline cellulose in an amount from 10.0 to 25.0% (w/w); and
croscarmellose sodium (Ac-Di-Sol) in an amount from 5.0 to 11.0% (w/w).
2. The composition of claim 1 , wherein the poly[(methyl methacrylate)-co-(methacrylic acid)] has a methyl methacrylate to methacrylic acid ratio of about 1:1.
3. The composition of claim 1 , wherein the sustaining polymer is hydroxypropyl methylcellulose acetate succinate high fine grade (HPMCAS-H).
4. The composition of claim 2 , comprising
Compound I, in an amount from 22.0 to 28.0% (w/w);
the poly[(methyl methacrylate)-co-(methacrylic acid)] having a methyl methacrylate to methacrylic acid ratio of about 1:1, in an amount from 22.0 to 28.0% (w/w);
sodium lauryl sulfate in an amount from 0.5 to 5.0% (w/w)
hydroxypropyl methylcellulose acetate succinate high fine grade in an amount from 13.0 to 28.0% (w/w);
microcrystalline cellulose (Avicel PH102) in an amount from 13.0 to 20.0% (w/w); and
croscarmellose sodium (Ac-Di-Sol) in an amount from 5.0 to 11.0% (w/w).
5. The composition of claim 1 , further comprising sodium lauryl sulfate in an amount from 1.25 to 1.75% (w/w).
6. The composition of claim 1 , further comprising sodium lauryl sulfate in an amount from 1.3 to 1.5% (w/w).
7. The composition of claim 1 , comprising
Compound I, in an amount of about 22.8% (w/w);
the poly[(methyl methacrylate)-co-(methacrylic acid)] having a methyl methacrylate to methacrylic acid ratio of about 1:1, in an amount of about 22.8% (w/w);
sodium lauryl sulfate in an amount of about 1.4% (w/w);
hydroxypropyl methylcellulose acetate succinate high fine grade in an amount of about 23.0% (w/w);
microcrystalline cellulose (Avicel PH102) in an amount of about 19.4% (w/w);
croscarmellose sodium (Ac-Di-Sol) in an amount of about 10.0% (w/w); and
magnesium stearate in an amount of about 0.5% (w/w).
8. The composition of claim 1 , further comprising colloidal silicon dioxide (Cab-O-Sil MP5) in an amount from 0.1 to 2.0% (w/w).
9. The composition of claim 8 , wherein the colloidal silicon dioxide (Cab-O-Sil MP5) is present in an amount from 0.50 to 1.5% (w/w).
10. The composition of claim 1 , comprising
Compound I, in an amount of about 22.8% (w/w);
the poly[(methyl methacrylate)-co-(methacrylic acid)] having a methyl methacrylate to methacrylic acid ratio of about 1:1, in an amount of about 22.8% (w/w);
sodium lauryl sulfate in an amount of about 1.4% (w/w);
hydroxypropyl methylcellulose acetate succinate high fine grade in an amount of about 23.0% (w/w);
microcrystalline cellulose (Avicel PH102) in an amount of about 18.4% (w/w);
croscarmellose sodium (Ac-Di-Sol) in an amount of about 10.0% (w/w);
colloidal silicon dioxide (Cab-O-Sil MP5) in an amount of about 1.0% (w/w); and
magnesium stearate in an amount of about 0.5% (w/w).
11. The composition of claim 8 , wherein the microcrystalline cellulose (Avicel PH102) in an amount from 10.0 to 30.0% (w/w).
12. The composition of claim 11 , wherein the microcrystalline cellulose (Avicel PH102) in an amount from 13.0 to 20.0% (w/w).
13. The composition of claim 11 , wherein the weight ratio of Compound I to the poly[(methyl methacrylate)-co-(methacrylic acid)] is about 1:1.
14. The composition of claim 11 , comprising
Compound I, in an amount of about 25.0% (w/w);
the poly[(methyl methacrylate)-co-(methacrylic acid)] having a methyl methacrylate to methacrylic acid ratio of about 1:1, in an amount of about 25.0% (w/w);
hydroxypropyl methylcellulose acetate succinate high fine grade in an amount of about 25.0% (w/w);
microcrystalline cellulose (Avicel PH102) in an amount of about 13.75% (w/w);
croscarmellose sodium (Ac-Di-Sol) in an amount of about 10.0% (w/w);
colloidal silicon dioxide (Cab-O-Sil MP5) in an amount of about 0.75% (w/w); and
magnesium stearate in an amount of about 0.5% (w/w).
15. The composition of claim 11 , comprising
Compound I, in an amount of about 22.9% (w/w);
the poly[(methyl methacrylate)-co-(methacrylic acid)] having a methyl methacrylate to methacrylic acid ratio of about 1:1, in an amount of about 22.9% (w/w);
hydroxypropyl methylcellulose acetate succinate high fine grade in an amount of about 22.9% (w/w);
microcrystalline cellulose (Avicel PH102) in an amount of about 19.8% (w/w);
croscarmellose sodium (Ac-Di-Sol) in an amount of about 10.0% (w/w);
colloidal silicon dioxide (Cab-O-Sil MP5) in an amount of about 1.0% (w/w); and
magnesium stearate in an amount of about 0.5% (w/w).