IP Library › Granted Patent US 12,145,934
Granted Patent B2
US 12,145,934 · App. 17/967,508 · Granted Nov 19, 2024

Azabenzimidazoles and their use as AMPA receptor modulators

Inventors: Michael K. Ameriks (San Diego, CA); Gang Chen (San Diego, CA); Bradley M. Savall (San Diego, CA); Devin M. Swanson (Carlsbad, CA); Wei Zhang (San Diego, CA); Dongpei Wu (San Diego, CA)
Assignee: Janssen Pharmaceutica NV
C07D471/04A61P25/00C07D471/14C07C2601/02C07C2601/04C07C2601/08C07C2601/14C07C2601/16
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Quick Facts
Patent No.
US 12,145,934
App. No.
17/967,508
Granted
Nov 19, 2024
Kind
B2
Abstract

Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Also provided herein are pharmaceutical compositions comprising compounds of Formula (I) and methods of using compounds of Formula (I).

Claims (4)

1. 2-(2-Fluoro-4-pyridyl)-3-(7-methyl-1H-indazol-5-yl)-5-(trifluoromethyl)imidazo[4,5-b]pyridine, or a pharmaceutically acceptable salt, N-oxide, or solvate thereof.

2. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable vehicle.

3. 2-(2-[18F]fluoro-4-pyridyl)-3-(7-methyl-1H-indazol-5-yl)-5-(trifluoromethyl)imidazo[4,5-b]pyridine, or a pharmaceutically acceptable salt, N-oxide, or solvate thereof.

4. A pharmaceutical composition comprising the compound of claim 3 and a pharmaceutically acceptable vehicle.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 25, 2024
From: AMERIKS, MICHAEL K.; CHEN, GANG; SAVALL, BRADLEY M.; SWANSON, DEVIN M.; WU, DONGPEI; ZHANG, WEI
To: JANSSEN PHARMACEUTICA NV
Reel/Frame 068083/0189 →
Continuity (4)
Continuation 17324520 · May 19, 2021
Continuation 15569299
Provisional Application 62154313 · Apr 29, 2015
Related Publication 20230114165A1 · Apr 13, 2023