Androgen receptor binding molecule and use thereof
An androgen receptor (AR) binding molecule has the structure of Formula (I) shown in the following: wherein E is CH 2 , G is CH, is OH, NH 2 , OTf or C≡C, X is CF 3 or trifluoromethylphenyl, is a single bond, and Y and Z are CH 2 ; or is absent, X is CF 3 , is a double bond, and Y and Z are CH.
1. A compound selected from the group consisting of the compounds as shown below:
Com-
pound
number
Structure
1
2
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53
2. A method for treating prostate cancer comprising:
administering a compound to a subject in need thereof to treat prostate cancer in the subject,
wherein the compound is selected from the group consisting of the compounds as shown below:
Com-
pound
number
Structure
1
2
3
4
5
6
7
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9
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11
12
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52
53
3. The method for treating prostate cancer as claimed in claim 2 , wherein the prostate cancer is prostate cancer with full length androgen receptor and/or androgen receptor splice variant 7.