Systems and methods for removal of blood and thrombotic material
A method of removing a thrombus including providing an aspiration catheter having an aspiration lumen and a supply lumen, providing a cassette configured to be connected to the supply lumen of the aspiration catheter, the cassette comprising a piston, and providing a pump base configured to receive the cassette in a movable engagement. The method also includes inserting the aspiration catheter into the vasculature of a patient, advancing the aspiration catheter to a region of interest, and operating the pump base to provide the fluid to the supply lumen of the aspiration catheter.
1. A method of removing a thrombus, comprising:
providing an aspiration catheter having an aspiration lumen and a supply lumen;
providing a cassette configured to be connected to the supply lumen of the aspiration catheter, the cassette comprising a piston;
providing a pump base configured to receive the cassette in a movable engagement, wherein the piston is selectively moved by the pump base to provide fluid to the aspiration catheter;
mounting the cassette to an elastomeric portion of a frame extending from a surface of the housing;
inserting the aspiration catheter into the vasculature of a patient;
advancing the aspiration catheter to a region of interest; and
operating the pump base to provide the fluid to the supply lumen of the aspiration catheter.
2. The method of claim 1 , wherein operating the pump base further comprises operating the pump base to cyclically actuate the piston of the cassette.
3. The method of claim 1 , further comprises engaging a saddle of the pump base with the piston of the cassette.
4. The method of claim 1 , wherein operating the pump base comprises activating a motor to turn a cam engaged with a saddle that receives the piston.
5. The method of claim 1 , wherein the cassette has a supply tube communicating with a supply cavity and an injection tube communicating with an injection cavity, the supply tube being configured to fluidly communicate with the fluid source and the injection tube being configured to fluidly communicate with the supply lumen of the aspiration catheter, the piston is movable within the supply cavity and the injection cavity to move a volume of the fluid into the injection tube.
6. The method of claim 5 , wherein operating the pump comprises cyclically actuating the piston so that the volume of the fluid injected per cycle of the piston can range from about 0.02 ml to about 41 ml.
7. A method of removing a thrombus, comprising:
providing an aspiration catheter having an aspiration lumen and a supply lumen, the supply lumen having a distal orifice opening into the aspiration lumen, a pressurized fluid from a fluid source in fluid communication with the supply lumen being provided through the distal orifice to form a jet having a spray pattern to interact with embolic material;
mounting a cassette configured to connect with the supply lumen of the aspiration catheter, the cassette comprising a piston;
mounting the cassette to an elastomeric frame extending from a surface of a housing of a pump base, the pump base is configured selectively move the piston to provide the fluid to the aspiration catheter;
inserting the aspiration catheter into the vasculature of a patient;
advancing the aspiration catheter to a region of interest; and
operating the pump base to provide the fluid to the supply lumen of the aspiration catheter so that the jet forms the spray pattern to interact with embolic material.
8. The method of claim 7 , wherein operating the pump base further comprises operating the pump base to cyclically actuate the piston of the cassette.
9. The method of claim 7 , further comprises engaging a saddle of the pump base with the piston of the cassette.
10. The method of claim 9 , wherein engaging the saddle comprising engaging a semi-cylindrical cavity of the saddle with a cylindrical engagement surface of the piston.
11. The method of claim 10 , wherein the cylindrical engagement surface is disposed between a pair of abutments.
12. The method of claim 7 , wherein mounting the cassette comprises mounting the cassette to an elastomeric frame extending from a surface of the housing.
13. The method of claim 7 , wherein operating the pump base comprises activating a motor to turn a cam engaged with a saddle that receives the piston.
14. The method of claim 7 , wherein the cassette has a supply tube communicating with a supply cavity and an injection tube communicating with an injection cavity, the supply tube being configured to fluidly communicate with the fluid source and the injection tube being configured to fluidly communicate with the supply lumen of the aspiration catheter, the piston is movable within the supply cavity and the injection cavity to move a volume of the fluid into the injection tube.
15. The method of claim 14 , wherein operating the pump comprises cyclically actuating the piston so that the volume of the fluid injected per cycle of the piston can range from about 0.02 ml to about 41 ml.
16. The method of claim 14 , wherein a usable volume of the injection cavity is about 0.07 ml to about 0.16 ml.
17. The method of claim 14 , wherein a usable volume ratio of a usable volume of the supply cavity and a usable volume of the injection cavity is between about 1.15 and about 2.0.
18. The method of claim 14 , wherein operating the pump so that a mean flow rate of fluid from the orifice is between about 5 ml/minute and about 100 ml/minute.
19. A method of removing a thrombus, comprising:
providing an aspiration catheter having an aspiration lumen and a supply lumen, the supply lumen having a distal orifice opening into the aspiration lumen, a pressurized fluid from a fluid source in fluid communication with the supply lumen being provided through the distal orifice to form a jet having a spray pattern to interact with embolic material;
mounting a cassette configured to connect with the supply lumen of the aspiration catheter, the cassette comprising a piston;
mounting the cassette to a pump base to mount a semi-cylindrical cavity of a saddle of the pump base with a cylindrical engagement surface of the piston, the pump base is configured selectively move the piston to provide the fluid to the aspiration catheter;
inserting the aspiration catheter into the vasculature of a patient;
advancing the aspiration catheter to a region of interest; and
operating the pump base to provide the fluid to the supply lumen of the aspiration catheter so that the jet forms the spray pattern to interact with embolic material.
20. A method of removing a thrombus, comprising:
providing an aspiration catheter having an aspiration lumen and a supply lumen;
providing a cassette configured to be connected to the supply lumen of the aspiration catheter, the cassette comprising a piston;
providing a pump base configured to receive the cassette in a movable engagement, wherein the piston is selectively moved by the pump base to provide fluid to the aspiration catheter;
mounting the cassette to the pump base to mount a semi-cylindrical cavity of a saddle of the pump base with a cylindrical engagement surface of the piston, the pump base is configured selectively move the piston to provide the fluid to the aspiration catheter;
inserting the aspiration catheter into the vasculature of a patient;
advancing the aspiration catheter to a region of interest; and
operating the pump base to provide the fluid to the supply lumen of the aspiration catheter.