Compositions and methods for the treatment of depression
The disclosure provides methods for treating major depressive disorder in a human patient having moderate or severe anhedonia. The methods comprise administering to the patient in need thereof an effective amount of aticaprant, or a pharmaceutically acceptable salt thereof. In some embodiments, the patient had an inadequate response to other antidepressant therapy prior to treatment with aticaprant. In other embodiments, the other antidepressant therapy comprised a selective serotonin reuptake inhibitor (SSRI), serotonin-norepinephrine reuptake inhibitor (SNRI), or a combination thereof.
1. A method for treating major depressive disorder in a human patient having anhedonia, the method comprising administering to the patient in need thereof an effective amount of aticaprant, or a pharmaceutically acceptable salt thereof, wherein the patient had an inadequate response to other antidepressant therapy prior to treatment with the aticaprant, or a pharmaceutically acceptable salt thereof, wherein the effective amount of the aticaprant is less than about 60 mg.
2. The method of claim 1 , wherein the other antidepressant therapy comprised one or more antidepressants.
3. The method of claim 2 , wherein the one or more antidepressants comprised a selective serotonin reuptake inhibitor (SSRI), serotonin-norepinephrine reuptake inhibitor (SNRI), or a combination thereof.
4. The method of claim 1 , further comprising treatment with an effective amount of one or more antidepressants.
5. The method of claim 4 , wherein the one or more antidepressants is a selective serotonin reuptake inhibitor (SSRI), serotonin-norepinephrine reuptake inhibitor (SNRI), or a combination thereof.
6. The method of claim 1 , wherein the aticaprant is S-aticaprant, or a pharmaceutically acceptable salt thereof.
7. The method of claim 1 , wherein the effective amount of the aticaprant is about 5 to about 50 mg.
8. The method of claim 1 , wherein the effective amount of the aticaprant is about 2 to about 15 mg.
9. The method of claim 1 , wherein the effective amount of the aticaprant is about 5 to about 15 mg.
10. The method of claim 1 , wherein the effective amount of aticaprant is about 5 to about 10 mg.
11. The method of claim 1 , wherein the effective amount of aticaprant is about 5 mg.
12. The method of claim 1 , wherein the aticaprant, or a pharmaceutically acceptable salt thereof, is administered orally.
13. The method of claim 1 , wherein the aticaprant, or a pharmaceutically acceptable salt thereof, is administered once daily.
14. The method of claim 1 , wherein the patient has mild anhedonia, moderate anhedonia, severe anhedonia, moderate to severe anhedonia, or prominent anhedonia.
15. The method of claim 1 , wherein the patient has moderate or severe anhedonia.
16. The method of claim 2 , further comprising treatment with an effective amount of one or more antidepressants.
17. The method of claim 16 , wherein the one or more antidepressants is a selective serotonin reuptake inhibitor (SSRI), serotonin-norepinephrine reuptake inhibitor (SNRI), or a combination thereof.
18. The method of claim 17 , wherein the patient has moderate or severe anhedonia.
19. The method of claim 18 , wherein the effective amount of the aticaprant is about 5 to about 10 mg.
20. The method of claim 19 , wherein the effective amount of the aticaprant is about 5 mg.
21. The method of claim 19 , wherein the aticaprant, or a pharmaceutically acceptable salt thereof, is administered orally and once daily.
22. The method of claim 20 , wherein the aticaprant, or a pharmaceutically acceptable salt thereof, is administered orally and once daily.
23. The method of claim 3 , further comprising treatment with an effective amount of one or more antidepressants.
24. The method of claim 23 , wherein the one or more antidepressants is a selective serotonin reuptake inhibitor (SSRI), serotonin-norepinephrine reuptake inhibitor (SNRI), or a combination thereof.
25. The method of claim 24 , wherein the patient has moderate or severe anhedonia.
26. The method of claim 25 , wherein the effective amount of the aticaprant is about 5 to about 10 mg.
27. The method of claim 26 , wherein the effective amount of the aticaprant is about 5 mg.
28. The method of claim 26 , wherein the aticaprant, or a pharmaceutically acceptable salt thereof, is administered orally and once daily.
29. The method of claim 27 , wherein the aticaprant, or a pharmaceutically acceptable salt thereof, is administered orally and once daily.