Anti-tumor compound and preparation method and use thereof
The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
1. An antibody-drug conjugate having a structure:
or a pharmaceutically acceptable salt thereof,
wherein n is the connection number, and n is selected from the group consisting of 1 to 10.
2. The antibody-drug conjugate or pharmaceutically acceptable salt thereof according to claim 1 , wherein n is 3 to 8.
3. The antibody-drug conjugate or pharmaceutically acceptable salt thereof according to claim 1 , wherein n is 2 to 6.
4. The antibody-drug conjugate or pharmaceutically acceptable salt thereof according to claim 1 , wherein n is 3 to 5.
5. The antibody-drug conjugate or pharmaceutically acceptable salt thereof according to claim 2 , wherein n is 3 to 4.
6. The antibody-drug conjugate or pharmaceutically acceptable salt thereof according to claim 1 , wherein n is 2.
7. The antibody-drug conjugate or pharmaceutically acceptable salt thereof according to claim 2 , wherein n is 3.
8. The antibody-drug conjugate or pharmaceutically acceptable salt thereof according to claim 2 , wherein n is 4.
9. The antibody-drug conjugate or pharmaceutically acceptable salt thereof according to claim 2 , wherein n is 5.
10. The antibody-drug conjugate or pharmaceutically acceptable salt thereof according to claim 2 , wherein n is 6.
11. The antibody-drug conjugate or pharmaceutically acceptable salt thereof according to claim 1 , wherein sacituzumab comprises a light chain comprising an amino acid sequence as set forth in SEQ ID NO: 35 and a heavy chain comprising an amino acid sequence as set forth in SEQ ID NO: 39.
12. The antibody-drug conjugate or pharmaceutically acceptable salt thereof according to claim 1 , wherein sacituzumab comprises a light chain variable region comprising the sequence of SEQ ID NO 27 and a heavy chain variable region comprising the sequence of SEQ ID NO 31.
13. A pharmaceutical composition comprising the antibody-drug conjugate or pharmaceutically acceptable salt thereof of claim 1 and a pharmaceutically acceptable carrier or diluent.
14. A method of treating cancer in a subject in need thereof, comprising administering to said subject the antibody-drug conjugate or pharmaceutically acceptable salt thereof of claim 1 .
15. The method of claim 14 , wherein the cancer is selected from the group consisting of lung cancer, kidney cancer, urinary tract carcinoma, colorectal cancer, prostatic cancer, glioblastoma multiforme, ovarian cancer, pancreatic cancer, breast cancer, melanoma, liver cancer, bladder cancer, stomach cancer and esophageal cancer.
16. The method of claim 15 , wherein the cancer is selected from the group consisting of ovarian cancer and colorectal cancer.
17. A method of producing the compound of claim 1 , comprising contacting sacituzumab with a compound of formula: