IP Library › Granted Patent US 12,178,892
Granted Patent B2
US 12,178,892 · App. 17/488,810 · Granted Dec 31, 2024

Compounds for positron emission tomography

Inventors: Iontcho R Vlahov (West Lafayette, IN); Christopher P Leamon (West Lafayette, IN); Philip S. Low (West Lafayette, IN); Garth L Parham (Largo, FL); Qingshou Chen (West Lafayette, IN)
Assignees: Purdue Research Foundation; Endocyte, Inc.
A61K51/0497A61K51/04A61K51/0459A61K51/0482
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Quick Facts
Patent No.
US 12,178,892
App. No.
17/488,810
Granted
Dec 31, 2024
Kind
B2
Abstract

Described herein are compounds, compositions, and methods for diagnosing and/or monitoring pathogenic disease using positron emission tomography. Also described are conjugates of the formula B-L-P, wherein B is a radical of a targeting agent selected from vitamin receptor binding ligands (such as folate), PSMA binding ligands, or PSMA inhibitors; L is a divalent linker comprising aspartic acid, lysine, or arginine, and P is a radical of an imaging agent or radiotherapy agent, such as a radionuclide or radionuclide containing group, or a radical of a compound capable of binding a radionuclide, such as a metal chelating group.

Claims (3)

1. A conjugate of formula

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a conjugate according to claim 1 and a pharmaceutically acceptable excipient.

Assignments (3)
CORRECTIVE ASSIGNMENT TO CORRECT THE THE INVENTOR NAME FROM QUINGSHOU CHEN TO QINGSHOU CHEN PREVIOUSLY RECORDED ON REEL 65912 FRAME 470. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Oct 22, 2024
From: LOW, PHILIP S.; CHEN, QINGSHOU
To: PURDUE RESEARCH FOUNDATION
Reel/Frame 069231/0657 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 19, 2023
From: LEAMON, CHRISTOPHER P.; VLAHOV, IONTCHO R.; PARHAM, GARTH L.
To: ENDOCYTE, INC.
Reel/Frame 065912/0453 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 19, 2023
From: LOW, PHILIP S.; CHEN, QUINGSHOU
To: PURDUE RESEARCH FOUNDATION
Reel/Frame 065912/0470 →
Continuity (6)
Continuation 16157024 · Oct 10, 2018
Continuation 15035936
Provisional Application 61904400 · Nov 14, 2013
Provisional Application 61904387 · Nov 14, 2013
Provisional Application 61909822 · Nov 27, 2013
Related Publication 20220125958A1 · Apr 28, 2022
Cited By (2)
US 12,473,265 US 12,655,115