IP Library › Granted Patent US 12,186,563
Granted Patent B2
US 12,186,563 · App. 17/187,654 · Granted Jan 7, 2025

Method and apparatus for neuromodulation treatments of pain and other conditions

Inventors: Anatoly Yakovlev (Santa Clara, CA); Daniel Pivonka (Del Mar, CA); Logan Palmer (Santa Monica, CA)
Assignee: Nalu Medical, Inc.
A61N1/36071A61B5/0022A61B5/0031A61B5/0538A61B5/1118A61B5/14539A61B5/24A61B5/389A61B5/40A61B5/4824A61B5/4836A61N1/0551A61N1/0553A61N1/0558A61N1/36125A61N1/37229A61N1/37235A61N1/37288A61N1/3787A61N2/002A61N2/006A61N2/008G16H40/67A61B2560/0219A61B2560/0242A61N1/36007A61N1/36057A61N1/36064A61N1/36067H02J50/00
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Quick Facts
Patent No.
US 12,186,563
App. No.
17/187,654
Granted
Jan 7, 2025
Kind
B2
Abstract

Systems, devices, and methods for neurostimulation using a combination of implantable and external devices to treat pain are disclosed.

Claims (28)

1. A neuromodulation apparatus comprising:

an implantable device configured to stimulate tissue, the implantable device comprising:

a resistor configured to measure leakage of the implantable device during a period of non-stimulation to provide single-point failure protection for the implantable device;

a first current source; and

a second current source,

wherein the implantable device is configured to ensure charge balance safety in stimulating the tissue by maintaining an active charge balance between the first and second current sources by matching the first and second current sources to operate in an H-bridge-like configuration, and

wherein the second current source is weaker than the first current source and a stimulation current of the tissue is determined by a current of the second current source; or

wherein the first and second current sources are cascoded and have parallel impedances of at least 1 Mohm.

2. The neuromodulation apparatus of claim 1 , wherein the implantable device further comprises a capacitor configured to accumulate charge during a calibration phase of the period of non-stimulation to monitor the implantable device.

3. The neuromodulation apparatus of claim 1 , wherein the resistor is switched into a leakage monitoring circuit of the implantable device to measure leakage at each of one or more electrodes of the implantable device during the period of non-stimulation.

4. The neuromodulation apparatus of claim 1 , wherein the implantable device is further configured to provide one or more of control circuit redundancy and leakage path blockage.

5. The neuromodulation apparatus of claim 4 , wherein the implantable device further comprises a mux switch to employ redundancy in a transmission or control gate of the implantable device to provide control circuit redundancy.

6. The neuromodulation apparatus of claim 4 , wherein the implantable device is further configured to digitally enable lines to prevent leakage if the transmission or the control gate of the tissue stimulator becomes stuck.

7. The neuromodulation apparatus of claim 1 , wherein the implantable device further comprises one or more isolated well structures to limit a current drive of the tissue stimulator.

8. The neuromodulation apparatus of claim 1 , wherein the implantable device further comprises a plurality of electrodes configured to deliver stimulation energy to the tissue, and wherein the implantable device is further configured to ensure charge balance safety by short-circuiting one or more of the plurality of electrodes to remove residual charge during a period of stimulation of the implantable device.

9. The neuromodulation apparatus of claim 8 , wherein:

the one or more electrodes are short-circuited for a time interval of about 3 time constants; or

the one or more electrodes are short-circuited when a Faradic resistance of the one or more electrodes is greater than 1 Mohm.

10. The neuromodulation apparatus of claim 1 , wherein the implantable device is further configured to monitor and control the stimulation current of the implantable device to minimize a voltage compliance effect on current balancing of the implantable device during a period of stimulation of the implantable device.

11. The neuromodulation apparatus of claim 10 , wherein the implantable device further comprises:

a voltage detection circuit at an output of the first or second current source configured to monitor and control delivery of the stimulation current to the tissue.

12. The neuromodulation apparatus of claim 1 , wherein the implantable device is further configured to maintain an operation of the first and second current sources in a linear range to ensure equal current during stimulation and recovery phases of the current source.

13. The neuromodulation apparatus of claim 12 , wherein the implantable device is configured to recover charge of the first and second current sources sequentially.

14. The neuromodulation apparatus of claim 1 , wherein the implantable device further comprises a single off-chip DC blocking capacitor that is configured to connect to at least one electrode of the implantable device through a switch during a period of stimulation of the implantable device.

15. The neuromodulation apparatus of claim 1 , wherein the implantable device is further configured to ensure that a recovery phase of the tissue stimulator does not forward bias ESD to one or more electrodes of the implantable device by grounding one or more switches of the implantable device that behave like linear loads.

16. The neuromodulation apparatus of claim 1 , wherein the first current source is one of a plurality of positive current sources and the second current source is one of a plurality of negative current sources, wherein the implantable device further comprises a plurality of channels each having one of the plurality of positive current sources and one of the plurality of negative current sources, and wherein the positive and negative current sources of each of the plurality of channels are configured to be matched.

17. The neuromodulation apparatus of claim 1 , wherein the implantable device further comprises a DC blocking capacitor configured to prevent exposure of the tissue to DC current.

18. The neuromodulation apparatus of claim 1 further comprising an external device configured to provide one or both of power and data to the implantable device.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 26, 2021
From: YAKOVLEV, ANATOLY; PIVONKA, DANIEL; PALMER, LOGAN
To: NALU MEDICAL, INC.
Reel/Frame 055435/0266 →
Continuity (7)
Continuation 16408989 · May 10, 2019
Continuation 15385729 · Dec 20, 2016
Continuation PCTUS2015036821 · Jun 19, 2015
Provisional Application 62077181 · Nov 8, 2014
Provisional Application 62053085 · Sep 19, 2014
Provisional Application 62015392 · Jun 21, 2014
Related Publication 20210196957A1 · Jul 1, 2021
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