Apparatus and methods for assisted breathing by transvascular nerve stimulation
A catheter may include electrodes for transvascular nerve stimulation. The electrodes may be positioned within lumens of the catheter and aligned with apertures in the outer wall of the catheter. The electrodes may produce focused electrical fields for stimulation of one or more nerves. In one embodiment, the catheter may include a set of proximal electrodes and a set of distal electrodes, and the proximal electrodes may stimulate a patient's left phrenic nerve and the distal electrodes may stimulate a patient's right phrenic nerve.
1. A method for stimulating a nerve, comprising:
inserting a catheter into a blood vessel of a patient, wherein during insertion an outer surface of a distal portion of the catheter has a first cross-sectional configuration having a first radius of curvature;
allowing the outer surface of the distal portion of the catheter to transform from the first cross-sectional configuration into a second cross-sectional configuration having a second radius of curvature greater than the first radius of curvature;
stimulating the nerve using at least one electrode of the distal portion of the catheter; and
transporting a fluid through a lumen fixed to the catheter, wherein the lumen is defined by a wall, and at least a portion of an outer surface of the wall is adapted to be exposed to the blood vessel when the catheter is in the second cross-sectional configuration.
2. The method of claim 1 , wherein allowing the distal portion of the catheter to transform includes allowing an adhesive to dissolve.
3. The method of claim 1 , wherein allowing the distal portion of the catheter to transform includes operating at least one control member.
4. The method of claim 1 , wherein the second cross-sectional configuration is a nearly flat configuration.
5. The method of claim 1 , wherein the at least one electrode is exposed to an exterior of the catheter through a window in an exterior wall of the catheter.
6. The method of claim 1 , further comprising positioning the distal portion of the catheter in a superior vena cava, and wherein the nerve is a right phrenic nerve.
7. The method of claim 1 , wherein the first cross-sectional configuration is circular, and the second cross-sectional configuration is nearly flat.
8. The method of claim 1 , wherein the at least one electrode of the distal portion of the catheter is in direct contact with the blood vessel.
9. A method for stimulating a nerve, comprising:
inserting a catheter into a blood vessel of a patient, wherein the catheter includes a plurality of leads surrounding an interior lumen fixed to the catheter;
allowing the plurality of leads to transform from a first configuration to a second configuration during which the leads move relative to one another;
when the plurality of leads is in the second configuration, stimulating the nerve using at least one electrode that is electrically coupled to a lead of the plurality of leads, and
transporting a fluid through the interior lumen, wherein the interior lumen is defined by a wall, and at least a portion of an outer surface of the wall is adapted to be exposed to the blood vessel when the catheter is in the second configuration.
10. The method of claim 9 , wherein the interior lumen is enclosed by a material, and the material is attached to the plurality of leads.
11. The method of claim 9 , wherein each lead of the plurality of leads is connected to an adjacent lead of the plurality of leads.
12. The method of claim 9 , wherein the first configuration is a cylindrical configuration, and the second configuration is a substantially planar configuration.
13. The method of claim 9 , wherein allowing the plurality of leads to transform includes allowing an adhesive to dissolve.
14. The method of claim 9 , wherein allowing the plurality of leads to transform includes operating at least one control member.
15. The method of claim 14 , wherein the at least one control member is a pull wire attached to a ribbon cable that includes the plurality of leads.
16. The method of claim 9 , wherein the nerve is a right phrenic nerve, and the method further comprises positioning the at least one electrode in a superior vena cava.
17. A method for stimulating a nerve, comprising:
inserting a catheter into a blood vessel of a patient, wherein the catheter includes a plurality of leads;
using a control member to transform a length of the catheter from a tubular configuration to an open configuration;
stimulating the nerve of the patient using at least one electrode that is electrically coupled to a lead of the plurality of leads, and
transporting a fluid through a lumen fixed to the catheter, wherein the lumen is defined by a wall, and at least a portion of an outer surface of the wall is adapted to be exposed to the blood vessel when the catheter is in the open configuration.
18. The method of claim 17 , wherein the plurality of leads are included in a ribbon cable, and the ribbon cable is biased towards the open configuration.
19. The method of claim 17 , wherein the control member is a pull wire.
20. The method of claim 17 , further comprising positioning the portion of the catheter in a superior vena cava.
21. The method of claim 17 , wherein the electrodes are exposed through corresponding windows in an exterior wall portion of the catheter.