Granted Patent B2

US 12,194,299 · App. 17/824,981 · Granted Jan 14, 2025

Inventors: Maria E. Bennett (Beachwood, OH); Joseph W. Boggs (Chapel Hill, NC); Warren M. Grill (Chapel Hill, NC); John Chae (Strongsville, OH)

Assignee: SPR Therapeutics, Inc.

A61N1/36071A61N1/36003A61N1/36017A61N1/36021A61N1/36057

Abstract

Claims (32)

1. A method of reducing a perception of pain, the method comprising:

percutaneously inserting a lead comprising at least one electrode in-vivo a therapeutically effective distance from a target afferent nerve fiber; and

electrically stimulating through the at least one electrode the target afferent nerve fiber at a first frequency of 1 kHz to 20 kHz and at a second frequency of 1 Hz to 30 Hz preventing stimulation-induced pain while generating a desired response in the target afferent nerve fiber to cause pain relief while avoiding generation of an unwanted response in a non-target nerve fiber, wherein electrically stimulating at the first frequency does not produce nerve damage, pain, or paresthesia.

2. The method of claim 1 , wherein the therapeutically effective distance is 1 mm.

3. The method of claim 1 , wherein the lead comprises first and second electrodes.

4. The method of claim 3 , wherein the first electrode applies the first frequency and the second electrode applies the second frequency.

5. The method of claim 1 , wherein the first frequency comprises 4 kHz to 20 KHz.

6. The method of claim 1 , wherein the second frequency comprises 12-16 Hz.

7. The method of claim 1 , wherein the first frequency comprises 4 kHz to 20 kHz and the second frequency comprises 12-16 Hz.

8. A method of reducing a perception of pain, the method comprising:

percutaneously inserting an electrode in-vivo a therapeutically effective distance from a target afferent nerve fiber; and

electrically stimulating through the electrode the target afferent nerve fiber with a first frequency stimulation of 1 kHz to 20 kHz and at a second frequency stimulation of 1 Hz to 30 Hz to generate a desired response in the target afferent nerve fiber while avoiding generation of unwanted responses in a non-target nerve fiber, wherein electrically stimulating through the electrode the target afferent nerve fiber with the first frequency stimulation does not produce nerve damage, pain, or paresthesia.

9. The method of claim 8 , wherein the desired response is pain relief.

10. The method of claim 9 , wherein the therapeutically effective distance from the target afferent nerve fiber is 1 mm.

11. The method of claim 8 , wherein the first frequency comprises 4 kHz to 20 kHz.

12. The method of claim 8 , wherein the second frequency comprises 12-16 Hz.

13. The method of claim 8 , wherein the first frequency comprises 4 kHz to 20 kHz and the second frequency comprises 12-16 Hz.

14. A method comprising:

applying a first frequency electrical stimulation of 1 kHz to 20 kHz to at least a portion of a peripheral nervous system through an electrode inserted percutaneously and spaced at a distance at least 1 mm away from a targeted nerve structure;

applying a second frequency electrical stimulation of 1 Hz to 30 Hz to the at least a portion of the peripheral nervous system through the electrode;

generating a stochastic response of action potentials in a plurality of target afferent sensory nerve fibers while avoiding action potentials in non-target small sensory afferent nerve fibers causing a reduction of perception of pain, wherein applying the first frequency of electrical stimulation does not produce nerve damage, pain, or paresthesia.

15. The method of claim 14 , wherein the first frequency comprises 4 kHz to 20 kHz.

16. The method of claim 14 , wherein the second frequency comprises 12-16 Hz.

17. The method of claim 14 , wherein the first frequency comprises 4 kHz to 20 kHz and the second frequency comprises 12-16 Hz.

18. A system to reduce a perception of pain comprising:

an electrode configured to be percutaneously inserted in-vivo;

an electrical pulse generator configured to apply electrical stimulation to at least a portion of a peripheral nervous system through the electrode at a first frequency of 1 kHz to 20 kHz generating a desired response and preventing stimulation-induced pain in at least one target afferent sensory nerve fiber while avoiding action potentials in non-target small sensory afferent nerve fibers causing a reduction of perception of pain and wherein the electrical pulse generator is configured to apply the electrical stimulation at a second frequency of 1 Hz to 30 Hz to generate a desired response in the target afferent sensory nerve fiber while avoiding generation of unwanted responses in a non-target nerve fiber, wherein the first frequency of electrical stimulation does not produce nerve damage, pain, or paresthesia.

19. The system of claim 18 , wherein the electrode is configured to be percutaneously inserted a therapeutically effective distance from the at least one target afferent sensory nerve fiber.

20. The system of claim 19 , wherein the therapeutically effective distance is 1 mm.

21. The system of claim 18 , wherein the first frequency comprises 4 kHz to 20 KHz.

22. The system of claim 18 , wherein the second frequency comprises 12-16 Hz.

23. The system of claim 18 , wherein the first frequency comprises 4 kHz to 20 kHz and the second frequency comprises 12-16 Hz.

Assignments (4)

Continuity (10)

References Cited (332)