Granted Patent
B2
US 12,201,644 · App. 17/474,765 · Granted Jan 21, 2025
Conjugation of lipophilic albumin-binding moiety to RNA for improved carrier-free in vivo pharmacokinetics and gene silencing
Inventors:
Craig L. Duvall (Nashville, TN); Samantha M. Sarett (Nashville, TN); Thomas A. Werfel (Nashville, TN)
Assignee:
Vanderbilt University
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Abstract
Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a RNA directly conjugated to an albumin-binding group to a subject in need thereof.
Claims (3)
1. A compound comprising siRNA functionalized with a dibenzocyclooctyne moiety and directly conjugated to 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000].
2. The compound of claim 1 , wherein the compound is complexed with albumin.
3. The compound of claim 1 , wherein the siRNA comprises a guide sequence that is complementary to an antisense sequence.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 15, 2021
From: DUVALL, CRAIG L; SARETT, SAMANTHA M; WERFEL, THOMAS A.
To: VANDERBILT UNIVERSITY
Reel/Frame 057495/0276 →
Continuity (3)
Provisional Application
62371619
· Aug 5, 2016
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