Hydroxyapatite, cosmetic, food, and method for producing the same
According to the present invention, provided is a carbonate- and magnesium-substituted hydroxyapatite having a particle size of 5 nm or more and 60 nm or less, wherein a portion of the calcium atoms in the hydroxyapatite are substituted with magnesium atoms and a portion of phosphate groups are substituted with carbonate groups.
1. A method for producing a suspension comprising carbonate- and magnesium-substituted hydroxyapatite having a part of calcium substituted with magnesium and a part of phosphate group substituted with a carbonate group, and comprising primary particles in a non-aggregated state, the primary particles having a particle size of 5 nm or more and 60 nm or less,
the method comprising:
preparing a mixed suspension comprising magnesium hydroxide and calcium hydroxide;
preparing a phosphoric acid aqueous solution; and
mixing the mixed suspension and the phosphoric acid aqueous solution by stirring in the presence of pure carbon dioxide gas, causing a neutralization reaction, and obtaining, in a liquid state, the suspension comprising the carbonate- and magnesium-substituted hydroxyapatite comprising the primary particles in the non-aggregated state.
2. A method for producing a suspension comprising carbonate- and magnesium-substituted hydroxyapatite having a part of calcium substituted with magnesium and a part of phosphate group substituted with a carbonate group, and comprising primary particles in a non-aggregated state, the primary particles having a particle size of 5 nm or more and 60 nm or less,
the method comprising:
preparing a first solution comprising magnesium salt and calcium salt;
preparing a second solution comprising phosphate salt; and
mixing the first solution and the second solution by stirring in the presence of pure carbon dioxide gas, causing a reaction, and obtaining, in a liquid state, the suspension comprising the carbonate- and magnesium-substituted hydroxyapatite comprising the primary particles in the non-aggregated state.
3. The method of claim 1 , wherein the stirring is executed with an ultrasonic vibration device.
4. The method of claim 2 , wherein the stirring is executed with an ultrasonic vibration device.