Synergistic composition for potentiating stabilized ATP
The present invention disclosed herein relates to a synergistic composition for potentiating stabilized ATP. Particularly, the invention provides the synergistic composition for improving cellular energy in a subject in need thereof. More particularly, the invention relates to compositions comprising synergistic combination therapeutically active ALCAR and MgAT which are present in the weight ratio of 1:0.002 to 1:1, along with pharmaceutically acceptable excipients. Further, the present composition is useful for improving tiredness, fatigue, cognition, memory, increase mental alertness, concentration, endurance, boost energy levels and wakefulness. It also useful for treating depression, anxiety related symptoms.
1. A synergistic composition for potentiating stabilized ATP, the synergistic composition comprising:
a therapeutically active exogenous blend consisting of acetyl L-carnitine and magnesium acetyl taurate; and
pharmaceutically acceptable excipients,
wherein the acetyl L-carnitine and the magnesium acetyl taurate are present in a weight ratio of 1:0.002 to 1:1.
2. The synergistic composition according to claim 1 , wherein the acetyl L-carnitine is present in a range of 50% to 99% by a total weight of the composition.
3. The synergistic composition according to claim 1 , wherein the magnesium acetyl taurate is present in a range of 1% to 50% by the total weight of the composition.
4. The synergistic composition according to claim 1 , wherein the pharmaceutically acceptable excipients are selected from a group consisting of a diluent present in a range of 1 to 30%, a binder present in a range of 0.1 to 25%, a lubricant present in a range of 0.1 to 10.0%, a glidant present in a range of 0.1 to 5.0%, an additive present in a range of 1 to 10%, a surfactant present in a range of 0.1 to 5.0%, a stabilizer present in a range of 0.1 to 5.0%, an antioxidant present in a range of 0.1 to 5.0%, and a plasticizer present in a range of 0.1 to 5.0%, by the total weight of the composition.
5. The synergistic composition according to claim 1 , wherein an administration of an effective unit dose of the synergistic composition improves ATP level by 65 to 575 folds over a normal cell control.
6. The synergistic composition according to claim 1 , wherein the acetyl L-carnitine and the magnesium acetyl taurate are present in a weight ratio of 1:0.005.
7. The synergistic composition according to claim 1 , wherein the acetyl L-carnitine and the magnesium acetyl taurate are present in a weight ratio of 1:0.01.
8. The synergistic composition according to claim 1 , wherein the acetyl L-carnitine and the magnesium acetyl taurate are present in a weight ratio of 1:1.
9. The synergistic composition according to claim 1 , wherein an oral administration of the synergistic composition improves tiredness, fatigue, weakness, cognition, memory, increase mental alertness, concentration, endurance, boost energy levels, wakefulness, conditions associated with ATP depletion, depression, or anxiety related symptoms.
10. The synergistic composition according to claim 5 , wherein the effective unit dose is formulated in a range of 10 mg to 1000 mg.