Granted Patent
B2
US 12,214,012 · App. 16/918,527 · Granted Feb 4, 2025
Combined preparations for the treatment of cancer
Assignee:
IMMUTEP S.A.S.
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Abstract
Combined preparations for the treatment of cancer are described. The combined preparations comprise: (a) LAG-3 protein, or a derivative thereof that is able to bind to MHC class II molecules; and (b) an anti-neoplastic agent, wherein the anti-neoplastic agent is a platinum-based anti-neoplastic agent or a topoisomerase I inhibitor. Methods for the treatment of cancer using the combined preparations are also described.
Claims (16)
1. A method of treating or ameliorating a cancer, which comprises:
administering to a subject in need of such treatment or amelioration an effective amount of:
a derivative of LAG-3 protein that is able to bind to MHC class II molecules, wherein the derivative comprises domains D1 and D2 of human LAG-3 protein, and wherein the derivative is fused to an Immunoglobulin Fc sequence; and
an anti-neoplastic agent, wherein the anti-neoplastic agent is a platinum-based anti-neoplastic agent or a topoisomerase I inhibitor; and
synergistically reducing tumor growth in the subject, the synergistic reduction of tumor growth being more than a sum of a reduction of tumor growth caused by administration to the subject of the derivative alone and the anti-neoplastic agent alone.
2. A method according to claim 1 , wherein the derivative and the anti-neoplastic agent are administered sequentially to the subject.
3. A method according to claim 1 , wherein the derivative is administered after the anti-neoplastic agent.
4. A method according to claim 2 , wherein the derivative and the anti-neoplastic agent are administered to the subject within 96 hours of each other.
5. A method according to claim 1 , wherein the derivative and the anti-neoplastic agent are co-administered to the subject.
6. A method according to claim 1 , wherein the derivative is administered to the subject at a dose which is a molar equivalent of 0.25-30 mg of LAG-3Ig fusion protein IMP321 per individual.
7. A method according to claim 1 , wherein a plurality of doses of the derivative is administered to the subject.
8. A method according to claim 1 , wherein a plurality of doses of the anti-neoplastic agent is administered to the subject.
9. A method according to claim 1 , wherein a dose of the derivative is administered before, with, or after each administration of two or more doses of the anti-neoplastic agent.
10. A method according to claim 1 , wherein the derivative comprises domains D1, D2, D3, and optionally D4 of human LAG-3 protein.
11. A method according to claim 1 , wherein the derivative of LAG-3 protein is IMP321.
12. A method according to claim 1 , wherein the anti-neoplastic agent is selected from the group consisting of oxaliplatin, carboplatin, and topotecan.
Priority Claims (1)
GB 1322626
· Dec 19, 2013
· national
Continuity (2)
Continuation
15105789
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