Granted Patent B2

US 12,226,537 · App. 17/590,388 · Granted Feb 18, 2025

Inventors: Johann Schreyer (Munich, DE); Erwin Knott (Poing, DE); Olivier Wolfgramm (Munich, DE)

Assignee: LivaNova Deutschland GmbH

A61L2/18A61L2/186A61M1/1686A61M1/169A61M1/3623A61M1/3666A61L2202/24A61M1/168A61M2205/366

Abstract

Claims (32)

1. A method for inhibiting microbial growth in a heat exchanging system used for human body temperature control during extracorporeal circulation, the method comprising:

coupling a temperature control liquid supply, a temperature control device and a heat exchanger, using fluid conduits, to form a temperature control circuit, wherein the temperature control device and the heat exchanger are disposed at separate locations;

circulating a temperature control liquid from the temperature control liquid supply through the temperature control circuit including at least one of the fluid conduits passing through the temperature control device and the heat exchanger, wherein the temperature control device is configured to regulate temperature of the temperature control liquid; and

circulating blood from a human body through the heat exchanger such that heat is exchanged between the blood and the temperature control liquid;

wherein the temperature control liquid includes a disinfectant to inhibit microbial growth in the temperature control device.

2. The method of claim 1 , wherein at least a portion of the temperature control liquid flows through a filter in a first direction and at least a portion of the temperature control liquid flows from the temperature control liquid supply in a second direction that is perpendicular to the first direction.

3. The method of claim 1 , wherein the disinfectant includes at least one of sodium hypochlorite, hydrogen peroxide, and citric acid.

4. The method of claim 1 , comprising measuring a concentration of the disinfectant in the temperature control liquid via a disinfectant sensor.

5. The method of claim 4 , wherein the disinfectant sensor is situated in the temperature control device.

6. The method of claim 4 , comprising adding additional disinfectant to the temperature control liquid based on the concentration measured by the disinfectant sensor.

7. The method of claim 6 , wherein the adding the additional disinfectant to the temperature control liquid includes passing a first portion of the temperature control liquid through a first container and passing a second portion of the temperature control liquid through a second container.

8. The method of claim 7 , wherein the adding the additional disinfectant to the temperature control liquid includes injecting the additional disinfectant into the temperature control liquid that is passing through the first container to obtain a predetermined concentration of the disinfectant in the temperature control liquid.

9. The method of claim 7 , wherein the adding the additional disinfectant to the temperature control liquid includes controlling, by a computer, the addition of the disinfectant to the temperature control liquid.

10. The method of claim 1 , wherein the temperature control liquid includes the disinfectant and water.

11. The method of claim 1 , wherein the heat exchanger includes a temperature control liquid side and a blood side, wherein circulating the temperature control liquid includes the temperature control liquid side circulating the temperature control liquid from the temperature control liquid supply to the temperature control device, and the blood side circulating blood from the human body through the heat exchanger, such that heat is exchanged between the blood and the temperature control liquid.

12. The method of claim 1 , wherein the heat exchanging system includes a disinfecting device coupled to the temperature control liquid supply, and at least one of a display and a remote control terminal, the method further comprising controlling settings of the disinfecting device using the display or the remote control terminal.

13. The method of claim 12 , wherein the disinfecting device includes at least first and second containers each containing a different disinfectant, wherein the controlling settings of the disinfecting device includes controlling an addition of a mixture of the disinfectants in the first and second containers to the temperature control liquid.

14. The method of claim 13 , wherein the temperature control liquid is water and the disinfecting device includes at least first, second, and third control valves controlling mixing of the temperature control liquid and disinfectant, wherein the method further comprises adjusting each of the first, second, and third control valves to supply water only through the first control valve, water and a first disinfectant from the first container through the second control valve, and water and a second disinfectant from the second container through the third control valve.

15. A method for inhibiting microbial growth in a heat exchanging system used for human body temperature control during extracorporeal circulation, the method comprising:

circulating a temperature control liquid, including a disinfectant to inhibit microbial growth, from a temperature control liquid supply through a temperature control circuit including a fluid conduit passing through a temperature control device and a heat exchanger, the heat exchanger including a temperature control liquid side and a blood side, wherein the temperature control device is configured to regulate temperature of the temperature control liquid; and

circulating blood from a human body through the heat exchanger such that heat is exchanged between the blood and the temperature control liquid;

disinfecting the temperature control device with the disinfectant in the temperature control liquid while circulating the blood from the human body through the heat exchanger;

wherein the circulating the temperature control liquid includes the temperature control liquid side circulating the temperature control liquid from the temperature control liquid supply to the temperature control device, and the blood side circulating blood from the human body through the heat exchanger, such that heat is exchanged between the blood and the temperature control liquid.

16. The method of claim 15 , further comprising measuring a concentration of the disinfectant in the temperature control liquid via a disinfectant sensor, and adding additional disinfectant to the temperature control liquid based on the concentration measured by the disinfectant sensor.

17. The method of claim 16 , wherein the adding the additional disinfectant to the temperature control liquid includes passing a first portion of the temperature control liquid through a first container and passing a second portion of the temperature control liquid through a second container.

18. The method of claim 17 , wherein the adding the additional disinfectant to the temperature control liquid includes injecting the additional disinfectant into the temperature control liquid that is passing through the first container to obtain a predetermined concentration of the disinfectant in the temperature control liquid.

19. A method for inhibiting microbial growth in a heat exchanging system used for human body temperature control during extracorporeal circulation, wherein such temperature control is achieved by using a temperature control liquid, the method comprising:

coupling a temperature control liquid supply, a temperature control device, a heat exchanger, and a disinfecting device using fluid conduits, to form a temperature control circuit, wherein the disinfecting device is coupled to the temperature control liquid supply and includes at least first and second containers each containing a different disinfectant;

controlling an addition of a mixture of the disinfectants in the at least first and second containers to the temperature control liquid in the disinfecting device;

circulating the temperature control liquid and the mixture of the disinfectants from the disinfecting device through the temperature control device and the heat exchanger, wherein the temperature control device is configured to regulate temperature of the temperature control liquid; and

circulating blood from a human body through the heat exchanger such that heat is exchanged between the blood and the temperature control liquid.

20. The method of claim 19 , wherein the temperature control liquid is water and the disinfecting device includes at least first, second, and third control valves controlling mixing of the temperature control liquid and the different disinfectants, wherein the method further comprises adjusting each of the at least first, second, and third control valves to supply water only through the first control valve, water and a first disinfectant from the first container through the second control valve, and water and a second disinfectant from the second container through the third control valve.

Priority Claims (1)

Continuity (4)

References Cited (132)