Granted Patent
B2
US 12,234,284 · App. 17/751,117 · Granted Feb 25, 2025
Treatment of kidney injury
Inventors:
Stuart Alexander Cook (Singapore, SG); Sebastian Schaefer (Singapore, SG); Anissa Anindya Widjaja (Singapore, SG)
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Abstract
Methods of treating and preventing kidney injury through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.
Claims (21)
1. A method of inhibiting the transition of tubular epithelial cells (TECs) to a mesenchymal cell-like phenotype in a subject, comprising administering to a subject in need thereof an effective amount of: an anti-interleukin 11 (IL-11) antibody or an antigen-binding fragment thereof which is an antagonist of IL-11-mediated signaling, thereby inhibiting the transition of TECs to a mesenchymal cell-like phenotype in the subject, wherein the subject in need thereof has proximal and/or distal TEC damage.
2. The method of claim 1 , wherein the subject is a subject suffering from impairment to renal function.
3. The method of claim 1 , wherein the anti-IL-11 antibody or antigen-binding fragment thereof comprises:
(i) a heavy chain variable (VH) region incorporating the following CDRs:
HC-CDR1 having the amino acid sequence of SEQ ID NO:40
HC-CDR2 having the amino acid sequence of SEQ ID NO:41
HC-CDR3 having the amino acid sequence of SEQ ID NO:42, ; and
(ii) a light chain variable (VL) region incorporating the following CDRs:
LC-CDR1 having the amino acid sequence of SEQ ID NO:43
LC-CDR2 having the amino acid sequence of SEQ ID NO:44
LC-CDR3 having the amino acid sequence of SEQ ID NO:45.
4. The method of claim 1 , wherein the anti-IL-11 antibody or antigen-binding fragment thereof comprises:
(i) a heavy chain variable (VH) region incorporating the following CDRs:
HC-CDR1 having the amino acid sequence of SEQ ID NO:34
HC-CDR2 having the amino acid sequence of SEQ ID NO:35
HC-CDR3 having the amino acid sequence of SEQ ID NO:36; and
(ii) a light chain variable (VL) region incorporating the following CDRs:
LC-CDR1 having the amino acid sequence of SEQ ID NO:37
LC-CDR2 having the amino acid sequence of SEQ ID NO:38
LC-CDR3 having the amino acid sequence of SEQ ID NO:39.
5. The method of claim 1 , wherein the subject is a subject in which expression of interleukin 11 (IL-11) is upregulated.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 27, 2022
From: COOK, STUART ALEXANDER; SCHAEFER, SEBASTIAN
To: NATIONAL UNIVERSITY OF SINGAPORE; SINGAPORE HEALTH SERVICES PTE LTD
Reel/Frame 062209/0036 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 27, 2022
From: WIDJAJA, ANISSA ANINDYA
To: NATIONAL UNIVERSITY OF SINGAPORE
Reel/Frame 062209/0072 →
Priority Claims (1)
GB 1902419
· Feb 22, 2019
· national
Continuity (2)
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