IP Library › Granted Patent US 12,239,573
Granted Patent B2
US 12,239,573 · App. 17/272,609 · Granted Mar 4, 2025

Drug therapy delivery systems and methods

Inventors: Peter J. Roeber (Oxford, PA); Jeffrey C. Towler (Wilmington, DE)
Assignee: W. L. Gore & Associates, Inc.
A61F9/0017
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Quick Facts
Patent No.
US 12,239,573
App. No.
17/272,609
Granted
Mar 4, 2025
Kind
B2
Abstract

Ocular medicament delivery devices are disclosed. In various embodiments, the ocular medicament delivery devices include multiple microporous layers arranged together to form a microporous body configured to meter dispensing of a medicament to surrounding tissues. In some embodiments, the ocular medicament delivery devices include one or more portions configured to resist tissue ingrowth, and one or more portions configured to permit tissue ingrowth. In some embodiments, the ocular medicament delivery devices deliver one or more medicaments useful in the treatment of glaucoma.

Claims (26)

1. An implantable delivery device for dispensing a medicament, the delivery device comprising: a first microporous layer including a plurality of pores sized to permit tissue ingrowth; a second microporous layer including a plurality of pores sized to permit tissue ingrowth; a third microporous layer coupled to the first microporous layer including a plurality of pores sized to resist tissue ingrowth; and a reservoir for receiving the medicament, the reservoir being defined between the third microporous layer and the second microporous layer, the reservoir having an inflated state when the reservoir is filled with a sufficient amount of the medicament and having a deflated state when the reservoir is devoid of the sufficient amount of the medicament, wherein when implanted in a body, uncoupled portions of the second and third microporous layers move toward each other when transitioning between the inflated and deflated states, such that the reservoir adopts a relatively flatter profile in the deflated state than in the inflated state, wherein at least a portion of the uncoupled portions of the second and third microporous layers are in contact when in the deflated state, wherein the third microporous layer is configured to meter a rate at which the medicament is eluted from the reservoir when the delivery device is implanted.

2. The device of claim 1 , further comprising a fourth microporous layer coupled to the second microporous layer such that the reservoir is defined between the third microporous layer and the fourth microporous layer.

3. The device of claim 2 , wherein the fourth microporous layer includes a plurality of pores sized to resist tissue ingrowth, and wherein the fourth microporous layer is permeable to the medicament.

4. The device of claim 2 , wherein the fourth microporous layer is impermeable to the medicament.

5. The device of claim 4 , wherein the fourth microporous layer includes an elastomer.

6. The device of claim 1 , wherein the first microporous layer includes an aperture configured to expose the third microporous layer.

7. The device of claim 1 , wherein the reservoir is configured to be refilled and emptied in situ.

8. The device of claim 1 , wherein the reservoir is configured to inflate to accommodate the medicament therein.

9. The device of claim 1 , wherein at least one of the first and second microporous layers comprise an expanded polytetrafluoroethylene (ePTFE) membrane.

10. The device of claim 1 , wherein a first portion of the third microporous layer is impermeable to the medicament, and wherein a second portion of the third microporous layer is permeable to the medicament.

11. The device of claim 10 , wherein the first portion of the third microporous layer includes an elastomer.

12. The device of claim 1 , wherein the delivery device is implantable within an eye.

13. The device of claim 12 , wherein the medicament is an ocular medicament for treating glaucoma.

14. The device of claim 1 , wherein the medicament is included within a fluid suspension of particles.

15. The device of claim 1 , wherein portions of the second microporous layer and the third microporous layer are inelastic.

16. An implantable delivery device for dispensing a medicament, the delivery device comprising: a first microporous layer coupled to a second microporous layer to define a reservoir having an inflated state and a deflated state, the first microporous layer comprising a first interior surface and an opposing second interior surface, and a body having an exterior surface, wherein the first interior surface is separable from the second interior surface when the reservoir is filled with a sufficient amount of medicament in the inflated state, wherein the first interior surface is configured to meter a dispensing of the medicament over a predetermined period of time, wherein when implanted in a body, uncoupled portions of the first and second microporous layers move toward each other when transitioning between the inflated and deflated states, such that the delivery device adopts a relatively flatter profile in the deflated state than the inflated state, wherein at least a portion of the uncoupled portions of the first and second microporous layers are in contact when in the deflated state, wherein the first interior surface is configured to resist tissue ingrowth, and wherein the exterior surface of the body is configured to permit tissue ingrowth.

17. The device of claim 16 , wherein at least a portion of the first interior surface is permeable to the medicament.

18. The device of claim 16 , wherein the second interior surface is impermeable to the medicament.

19. A delivery device for dispensing a medicament comprising: a microporous body including a first microporous layer, a second microporous layer, and a third microporous layer, the first microporous layer being situated between the second and third microporous layers, the first microporous layer including a plurality of pores sized to resist tissue ingrowth, where the second and third microporous layers each include a plurality of pores sized to permit tissue ingrowth; and a medicament reservoir located between the first microporous layer and the third microporous layer, the medicament reservoir having an expanded state and a collapsed state, wherein when implanted in a body, uncoupled portions of the first and third microporous layers move toward each other when transitioning between the expanded and collapsed states, such that the medicament reservoir adopts a relatively flatter profile in the collapsed state than in the expanded state, wherein at least a portion of the uncoupled portions of the first and third microporous layers are in contact when in the collapsed state.

20. The device of claim 19 , wherein the first microporous layer includes a metering portion for dispensing a medicament over a period of time.

21. The device of claim 19 , wherein the second and third microporous layers define an exterior of the delivery device.

22. The device of claim 19 , wherein the first microporous layer is coupled to the second microporous layer.

23. The device of claim 22 , wherein the second microporous layer includes an aperture configured to expose the first microporous layer.

24. A medicament metering device having an exterior surrounding an interior that defines a medicament reservoir, the device comprising: a first stratum including a first microporous layer and a second microporous layer, the first microporous layer being configured to resist tissue ingrowth and the second microporous layer being configured to permit tissue ingrowth, the first microporous layer defining a portion of the interior and the second microporous layer defining a portion of the exterior; and a second stratum coupled to the first stratum such that the medicament reservoir is defined between the first and second strata, a portion of the first microporous layer of the first stratum being permeable to a medicament disposable within the medicament reservoir, wherein the medicament reservoir has expanded state and a collapsed state, and wherein when implanted in a body, uncoupled portions of the first and second strata move toward each other when transitioning between the expanded and collapsed states, such that the medicament reservoir adopts a relatively flatter profile in the collapsed state than in the expanded state, wherein at least a portion of the uncoupled portions of the first and second strata are in contact when in the collapsed state.

25. The device of claim 24 , wherein the medicament reservoir is defined between portions of the first and second strata that are not coupled to one another such that the uncoupled portions of the first and second strata are free to deflect relative to one another.

26. The device of claim 24 , wherein the second stratum includes a third microporous layer and a fourth microporous layer, the third microporous layer of the second stratum being configured to resist tissue ingrowth and the fourth microporous layer of the second stratum being configured to permit tissue ingrowth, wherein the third microporous layer of the second stratum defines a portion of the interior and the fourth microporous layer defines a portion of the exterior.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 2, 2021
From: ROEBER, PETER J.; TOWLER, JEFFREY C.
To: W. L. GORE & ASSOCIATES, INC.
Reel/Frame 056415/0594 →
Continuity (2)
Provisional Application 62724425 · Aug 29, 2018
Related Publication 20210346197A1 · Nov 11, 2021
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