Generating irreversible electroporation and radiofrequency-abaltion (IRE/RFA) waveforms
An irreversible electroporation and radio frequency ablation (IRE/RFA) generator includes an IRE pulse generator, harmonic filtration circuitry, and a waveform interleaver. The IRE pulse generator is configured to generate biphasic IRE pulses. The harmonic filtration circuitry is configured to convert the IRE pulses into an RF signal. The waveform interleaver, which is configured to receive the IRE pulses and the RF signal and generate an output signal having a composition of the adapted IRE pulses having a final shape and repetition rate, the converted RF sinusoidal signal, or a combined IRE/RFA output signal, by switching between the received IRE square pulses and the received converted RF sinusoidal signal.
1. A system for combining irreversible electroporation and radio frequency ablation (IRE/RFA), comprising:
an IRE pulse generator configured to generate biphasic IRE square pulses;
a biphasic pulse shaper, configured and controlled by a processor, to adapt the biphasic IRE square pulses to IRE pulses having a final shape and repetition rate;
one or more harmonic filters, configured and controlled by the processor, to convert the biphasic IRE square pulses into an RF sinusoidal signal; and
a waveform interleaver comprising switching circuitry, which is configured and controlled by the processor, to receive the IRE square pulses and the converted RF sinusoidal signal and generate an output signal having a composition comprising one of: i) the adapted IRE pulses having a final shape and repetition rate, ii) the converted RF sinusoidal signal, or iii) a combined IRE/RFA output signal that switches between the adapted IRE square pulses and the converted RF sinusoidal signal.
2. The system of claim 1 , wherein the combined IRE/RFA output signal comprises one or more of the IRE square pulses with one or more periods of the converted RF sinusoidal signal interleaved in alternation into a single waveform.
3. The system of claim 1 , wherein the composition of the generated output signal is one-hundred percent (100%) IRE square pulses.
4. The system of claim 1 , wherein the composition of the generated output signal is one-hundred percent (100%) converted RF sinusoidal signal.
5. The system of claim 1 , wherein the composition of the generated output signal is a ratio between one-hundred percent (100%) IRE square pulses and one-hundred percent (100%) converted RF sinusoidal signal.
6. A method for combining irreversible electroporation and radio frequency ablation (IRE/RFA), comprising:
generating biphasic IRE square pulses;
adapting the biphasic IRE square pulses to IRE pulses having a final shape and repetition rate;
using one or more harmonic filters, configured by a processor, converting the IRE square pulses into an RF sinusoidal signal; and
receiving the IRE square pulses and the converted RF sinusoidal signal and generating, by a waveform interleaver comprising switching circuitry controlled by the processor, in response to receiving an input via a user interface, an output signal having a composition comprising one of: i) the adapted IRE pulses having a final shape and repetition rate, ii) the converted RF sinusoidal signal, or iii) a combined IRE/RFA output signal that switches between the adapted IRE square pulses and the converted RF sinusoidal signal.
7. The method of claim 6 , wherein the combined IRE/RFA output signal comprises one or more of the IRE square pulses with one or more periods of the converted RF sinusoidal signal interleaved in alternation into a single waveform.
8. The method of claim 6 , wherein the composition of the generated output signal is one-hundred percent (100%) IRE square pulses.
9. The method of claim 6 , wherein the composition of the generated output signal is one-hundred percent (100%) converted RF sinusoidal signal.
10. The method of claim 6 , wherein the composition of the generated output signal is a ratio between one-hundred percent (100%) IRE square pulses and one-hundred percent (100%) converted RF sinusoidal signal.
11. A computer program product, comprising a non-transitory computer-readable medium having computer-readable program code embodied therein to be executed by one or more processors, the program code including instructions to:
cause biphasic IRE square pulses to be generated;
cause the biphasic IRE square pulses to be adapted to IRE pulses having a final shape and repetition rate;
cause, using one or more harmonic filters, the IRE square pulses to be converted into an RF sinusoidal signal; and
receive the IRE square pulses and the converted RF sinusoidal signal and generate, by a waveform interleaver comprising switching circuitry controlled by the processor, in response to receiving an input via a user interface, an output signal having a composition comprising one of: i) the adapted IRE pulses having a final shape and repetition rate, ii) the converted RF sinusoidal signal, or iii) a combined IRE/RFA output signal that switches between the adapted IRE square pulses and the converted RF sinusoidal signal.
12. The computer program product of claim 11 , wherein the combined IRE/RFA output signal comprises one or more of the IRE square pulses with one or more periods of the converted RF sinusoidal signal interleaved in alternation into a single waveform.
13. The computer program product of claim 11 , wherein the composition of the generated output signal is one-hundred percent (100%) IRE square pulses.
14. The computer program product of claim 11 , wherein the composition of the generated output signal is one-hundred percent (100%) converted RF sinusoidal signal.
15. The computer program product of claim 11 , wherein the composition of the generated output signal is a ratio between one-hundred percent (100%) IRE square pulses and one-hundred percent (100%) converted RF sinusoidal signal.